Conventional / global / constitutive KO
●3 Models Available
Mpo Conditional Knockout, Knockout mouse models
Browse 3 Mpo mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Mpo conditional knockout mouse, Mpo knockout mouse. Contact us for availability and fast turnaround.
Why model Mpo
Mpo, the mouse ortholog of human MPO, encodes myeloperoxidase, the dominant protein of neutrophil azurophilic granules, synthesized as a glycosylated precursor and processed into a disulfide linked homodimer of heavy and light chains each holding a covalently bound heme. Using hydrogen peroxide generated by NADPH oxidase, it oxidizes chloride to hypochlorous acid and tyrosine to reactive radicals, producing the 3-chlorotyrosine footprint of oxidative host defense and contributing to neutrophil extracellular trap formation and lipoprotein modification in atherosclerosis. Two translational asymmetries shape design. Human MPO deficiency is comparatively common yet clinically mild, while myeloperoxidase is the principal autoantigen of ANCA associated microscopic polyangiitis, and mouse neutrophils carry substantially less enzyme than human cells, which blunts murine oxidative readouts. Nulls suit host defense and vasculitis initiation questions, catalytically inactive knockins separate enzymatic from antigenic roles, and humanization is the appropriate allele for autoantibody epitope mapping and inhibitor programs.
What Mpo mouse models are available?
ingenious targeting laboratory offers 3 distinct Mpo (MPO) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Mpo model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Mpo allele types
Knockout, conditional, knockin, humanized, and related paths for Mpo (human MPO). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Mpo catalog models
3 Mpo lines with QC documentation and technical support. Mpo floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Mpo (MPO) from ITL supported projects.
- Compound heterozygous RYR1-RM mouse model reveals disease pathomechanisms and muscle adaptations to promote postnatal survivalLiang C, Malik S, He M, Groom L, Ture SK, O'Connor TN, Morrell CN, Dirksen RT. (2024). FASEB J 20(38): e70120
- The stress response regulator HSF1 modulates natural killer cell anti-tumour immunityHockemeyer K, Sakellaropoulos T, Chen X, Ivashkiv O, Sirenko M, Zhou H, Gambi G, Battistello E, Avrampou K, Sun Z, Guillamot M, Chiriboga L, Jour G, Dolgalev I, Corrigan, K, Bhatt, Osman I, Tsirigos A, Kourtis N, Aifantis I. (2024). Nat Cell Bio 26(10): 1734-1744
- Loss-of-function OGFRL1 variants identified in autosomal recessive cherubism familiesKittaka M, Mizuno N, Morino H, Yoshimoto T, TZhu T, Liu S, Wang Z, Mayahara K, Iio K, Kondo K, Kondo T, Hayashi T, Coghlan S, Teno Y, Anh Phung Doan A, Levitan M, Choi RB, Matsuda S, Ouhara K, Wan J, Cassidy AM, Pelletier S, Nampoothiri S, Urtizberea AJ, Robling AG, Ono M, Kawakami H, Reichenberger EJ, Ueki Y. (2024). JBMR Plus 8(6): ziae050
- Lack of evidence for participation of TMEM150c/TENTONIN3 in sensory mechanotransduction.Ojeda-Alonso J, Bégay V, Garcia-Contreras J, Campos-Pérez A, Purfürst B, Lewin G. (2022). J Gen Physiol 154(12): e202213098
- Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanismMcGuire MR, Mukhopadhyay D, Myers SL, Mosher EP, Brookheart RT, Kammers K, Sehgal A, Selen ES, Wolfgang MJ, Bumpus NN, Espenshade PJ. (2021). J Biol Chem 297(5): 101316
Looking for a Mpo mouse model?
We have 3 Mpo models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Mpo Mouse Model Types
A Mpo knockout mouse has the Mpo gene permanently inactivated, enabling loss of function studies. A Mpo conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Mpo, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Mpo organized by modification type. Each URL is indexable and matches common search patterns.