Conventional / global / constitutive KO
●1 Model Available
Mtor Conditional Knockout mouse model
Browse 1 Mtor mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Mtor
Mtor, the mouse ortholog of human MTOR, encodes a phosphatidylinositol kinase-related serine and threonine kinase with HEAT repeats, FAT, FRB, kinase, and FATC domains that nucleates two distinct complexes: mTORC1, containing Raptor and Mlst8, is recruited to lysosomes by Rag GTPases in response to amino acids and activated by Rheb-GTP under growth factor and energy input, phosphorylating Rps6kb1 and Eif4ebp1 to drive translation while suppressing Ulk1-dependent autophagy; mTORC2, containing Rictor, Mapkap1, and Mlst8, phosphorylates Akt at Ser473. Rapamycin acts allosterically by bridging Fkbp12 to the FRB domain, inhibiting mTORC1 acutely and mTORC2 only chronically. Homozygous deletion is lethal shortly after implantation, so conditional alleles are required, and the rapamycin-resistant Ser2035Thr knockin remains the definitive genetic test of on-target drug action. Kinase-dead and activating knockins separate scaffolding from catalysis, while Rptor and Rictor floxed alleles resolve complex-specific questions that Mtor deletion cannot.
What Mtor mouse models are available?
ingenious targeting laboratory offers 1 distinct Mtor (MTOR) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Mtor model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Mtor allele types
Knockout, conditional, knockin, humanized, and related paths for Mtor (human MTOR). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Mtor catalog models
1 Mtor line with QC documentation and technical support. Mtor floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Mtor-Flox
Conditional KnockoutKO/CKO mice
embryo cryopreservationCKO 200196
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Mtor (MTOR) from ITL supported projects.
- Lysosomal NKG7 restrains mTORC1 activity to promote CD8+ T cell durability and tumor controlHam H, Hirdler JB, Bihnam DT, Mao Z, Gicobi JK, Macedo BG, Rodriguez-Quevedo MF, Schultz DF, Correia C, Zhong J, Martinez KE, Banuelos A, Ashton DS, Lagnado AB, Guo R, Pessoa R, Pandey A, Li H, Lucien F, Borges da Silva H, Dong H, Billadeau DD. (2025). Nat Commun 16(1): 1628.
Looking for a Mtor mouse model?
We have 1 Mtor model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
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Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Mtor Mouse Model Types
A Mtor conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Mtor, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Mtor organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Mtor.