Conventional / global / constitutive KO
●2 Models Available
Mycn Conditional Knockout, Knockin mouse models
Browse 2 Mycn mouse models including conditional knockout, knockin variants from ingenious targeting laboratory. Available as Mycn conditional knockout mouse, Mycn knockin mouse. Contact us for availability and fast turnaround.
Why model Mycn
Encoding N-Myc, Mycn is the mouse ortholog of human MYCN and produces a basic helix-loop-helix leucine zipper factor that heterodimerizes with Max, occupies E-box elements, and drives ribosome biogenesis and cell cycle programs in neural crest, neuroblast, and cerebellar progenitors; like c-Myc it carries the Thr58 and Ser62 phosphodegron read by Fbxw7, but Aurora kinase A binding stabilizes the protein against that pathway, which is the mechanistic basis for Aurora A inhibitor strategies in MYCN-amplified disease. Genomic amplification defines high-risk neuroblastoma and also occurs in medulloblastoma and neuroendocrine prostate cancer. Homozygous nulls die in mid-gestation with neural, cardiac, and lung defects, so conditional deletion is required for progenitor studies, whereas lineage-restricted overexpression modeled on tyrosine hydroxylase promoter-driven designs remains the standard tumor-initiating allele, and a Thr58Ala knockin isolates degron control from expression level. Myc can substitute at the endogenous locus, so paralog dosage and driver specificity govern the phenotype.
What Mycn mouse models are available?
ingenious targeting laboratory offers 2 distinct Mycn (MYCN) catalog mouse models, featuring conditional knockout and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Mycn model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Mycn allele types
Knockout, conditional, knockin, humanized, and related paths for Mycn (human MYCN). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Mycn catalog models
2 Mycn lines with QC documentation and technical support. Mycn floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Mycn mouse model?
We have 2 Mycn models available — including Conditional Knockout, Knockin types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Mycn Mouse Model Types
A Mycn conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Mycn, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Mycn knockin models carry a precisely inserted sequence at the Mycn locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Mycn organized by modification type. Each URL is indexable and matches common search patterns.