Conventional / global / constitutive KO
●2 Models Available
Npm1 Conditional Knockout, Knockout mouse models
Browse 2 Npm1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Npm1 conditional knockout mouse, Npm1 knockout mouse. Contact us for availability and fast turnaround.
Why model Npm1
Npm1 encodes the mouse ortholog of human NPM1, a pentameric nucleolar phosphoprotein that shuttles between nucleolus, nucleoplasm, and cytoplasm, chaperoning ribosomal proteins and histones, controlling ribosome biogenesis, and stabilizing ARF and p53 through nucleolar sequestration. The defining leukemogenic lesion is not loss but a frameshift in the terminal exon, most often the type A tetranucleotide duplication at W288, which ablates the C-terminal tryptophans and creates a new leucine-rich nuclear export signal, producing cytoplasmic NPM1c, sustained HOX program expression, and XPO1 dependence in acute myeloid leukemia. Because homozygous deletion is embryonic lethal with hematopoietic and midline defects while heterozygotes show genomic instability, design is explicit: humanized exon 12 frameshift knockins interrogate NPM1c leukemia and menin or exportin inhibitor response, whereas conditional nulls test nucleolar stress and ribosome biogenesis dependence. Paralogs Npm2 and Npm3 do not substitute functionally, and a cooperating Flt3 internal tandem duplication allele markedly shortens latency.
What Npm1 mouse models are available?
ingenious targeting laboratory offers 2 distinct Npm1 (NPM1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Npm1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Npm1 allele types
Knockout, conditional, knockin, humanized, and related paths for Npm1 (human NPM1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Npm1 catalog models
2 Npm1 lines with QC documentation and technical support. Npm1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Npm1 mouse model?
We have 2 Npm1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Npm1 Mouse Model Types
A Npm1 knockout mouse has the Npm1 gene permanently inactivated, enabling loss of function studies. A Npm1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Npm1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Npm1 organized by modification type. Each URL is indexable and matches common search patterns.