Conventional / global / constitutive KO
●5 Models Available
Nrxn2 Conditional Knockout, Knockout mouse models
Browse 5 Nrxn2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Nrxn2 conditional knockout mouse, Nrxn2 knockout mouse. Contact us for availability and fast turnaround.
Why model Nrxn2
Although often treated as the minor paralog, Nrxn2 encodes the mouse ortholog of human NRXN2, an alpha and beta neurexin pair whose extracellular LNS and EGF modules bind neuroligins, LRRTMs, and cerebellin adaptors to align presynaptic release machinery with postsynaptic receptor fields. Its cytoplasmic tail terminates in a PDZ-binding motif engaging CASK, linking the adhesion complex to voltage-gated calcium channels and the active zone. Truncating NRXN2 variants have been reported in autism and schizophrenia pedigrees, and alpha-Nrxn2 null mice show altered social behavior and anxiety with region-specific transmission deficits. Design decisions therefore split between conditional alpha-specific exon removal, beta-selective ablation, splice site 4 fixed knockins, and humanization for variant testing. Given strong functional overlap with Nrxn1 and Nrxn3, compound conditional alleles are usually required to unmask phenotypes, and pairing them with an interneuron or projection-specific Cre determines whether readouts are electrophysiological, behavioral, or ultrastructural.
What Nrxn2 mouse models are available?
ingenious targeting laboratory offers 5 distinct Nrxn2 (NRXN2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 5 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Nrxn2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Nrxn2 allele types
Knockout, conditional, knockin, humanized, and related paths for Nrxn2 (human NRXN2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Nrxn2 catalog models
5 Nrxn2 lines with QC documentation and technical support. Nrxn2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Nrxn2-Flox(2)
Conditional KnockoutKO/CKO mice
sperm cryopreservationCKO 231809 - Order
Nrxn2-Flox
Conditional KnockoutKO/CKO mice
sperm cryopreservationCKO 231808 - Order
Nrxn2-KO(4)
KnockoutKO/CKO mice
sperm cryopreservationKO 235035 - Order
Nrxn2-KO(2)
KnockoutKO/CKO mice
sperm cryopreservationKO 235034 - Order
Nrxn2-KO
KnockoutKO/CKO mice, disease model mice
embryo cryopreservationKO 201023
Looking for a Nrxn2 mouse model?
We have 5 Nrxn2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model5
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Nrxn2 Mouse Model Types
A Nrxn2 knockout mouse has the Nrxn2 gene permanently inactivated, enabling loss of function studies. A Nrxn2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Nrxn2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Nrxn2 organized by modification type. Each URL is indexable and matches common search patterns.