Conventional / global / constitutive KO
●3 Models Available
Pcsk9 Conditional Knockout, Knockout mouse models
Browse 3 Pcsk9 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Pcsk9 conditional knockout mouse, Pcsk9 knockout mouse. Request a quote within 24 hours.
Why model Pcsk9
Pcsk9, ortholog of human PCSK9, encodes a secreted proprotein convertase that abandons catalysis after autoproteolysis: the cleaved prodomain remains lodged in the active site, and the mature protein instead acts as a chaperone, its catalytic domain gripping the EGF-A repeat of the LDL receptor at the hepatocyte surface and rerouting the complex from recycling endosome to lysosome, lowering surface receptor density and raising plasma LDL cholesterol. Human genetics supplies both directions, with gain-of-function alleles such as D374Y causing autosomal dominant hypercholesterolemia and loss-of-function alleles such as Y142X and R46L conferring lifelong protection. Because monoclonal antibodies and siRNA therapeutics recognize human sequence, locus humanization is usually the decisive design for pharmacology, whereas hepatic conditional nulls and D374Y knockins address receptor trafficking and lesion burden. Nulls are viable and hypocholesterolemic, so lethality is no constraint; pair alleles with Ldlr or Apoe backgrounds suited to the atherosclerosis endpoint.
What Pcsk9 mouse models are available?
ingenious targeting laboratory offers 3 distinct Pcsk9 (PCSK9) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pcsk9 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pcsk9 allele types
Knockout, conditional, knockin, humanized, and related paths for Pcsk9 (human PCSK9). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pcsk9 catalog models
3 Pcsk9 lines with QC documentation and technical support. Pcsk9 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Pcsk9 mouse model?
We have 3 Pcsk9 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pcsk9 Mouse Model Types
A Pcsk9 knockout mouse has the Pcsk9 gene permanently inactivated, enabling loss of function studies. A Pcsk9 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pcsk9, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Pcsk9 organized by modification type. Each URL is indexable and matches common search patterns.
Tissue-specific options
Catalog backed tissue and driver restricted routes for Pcsk9.