Conventional / global / constitutive KO
●1 Model Available
Pgk1 Conditional Knockout mouse model
Browse 1 Pgk1 mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Pgk1
Pgk1 is the mouse ortholog of human PGK1 and encodes phosphoglycerate kinase 1, the enzyme that transfers the high-energy phosphate of 1,3-bisphosphoglycerate to ADP, generating the first net ATP of glycolysis and yielding 3-phosphoglycerate that also feeds the serine biosynthesis branch. The gene is X-linked and ubiquitously expressed, and the protein moonlights beyond canonical glycolysis, acting as a disulfide reductase that liberates angiostatin from plasmin and, in some settings, entering mitochondria to phosphorylate pyruvate dehydrogenase kinase 1. Recessive human deficiency produces hemolytic anemia, myopathy and neurological disease with hemizygous male presentation. Because complete loss removes a non-redundant ATP-generating step, conditional floxed alleles are the practical format, with patient-matched knockins preserving residual activity for erythroid and muscle phenotyping. The testis-restricted paralog Pgk2 exists but does not cover somatic tissue. Match the allele to endpoint, using erythroid, muscle or neural Cre drivers as the biology dictates.
What Pgk1 mouse models are available?
ingenious targeting laboratory offers 1 distinct Pgk1 (PGK1) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pgk1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pgk1 allele types
Knockout, conditional, knockin, humanized, and related paths for Pgk1 (human PGK1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pgk1 catalog models
1 Pgk1 line with QC documentation and technical support. Pgk1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Pgk1-Flox
Conditional KnockoutKO/CKO mice
sperm cryopreservationCKO 234478
Looking for a Pgk1 mouse model?
We have 1 Pgk1 model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pgk1 Mouse Model Types
A Pgk1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pgk1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Pgk1 organized by modification type. Each URL is indexable and matches common search patterns.