Conventional / global / constitutive KO
●3 Models Available
Pink1 Conditional Knockout, Knockout mouse models
Browse 3 Pink1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Pink1 conditional knockout mouse, Pink1 knockout mouse. Contact us for availability and fast turnaround.
Why model Pink1
Mitochondrial quality control initiates with Pink1, the mouse ortholog of human PINK1, encoding a serine/threonine kinase whose N-terminal targeting sequence normally drives import, MPP and PARL cleavage, and rapid N-end rule degradation. On depolarized mitochondria import arrests, PINK1 accumulates on the TOM complex, autophosphorylates, and phosphorylates ubiquitin at Ser65 plus the parkin ubiquitin-like domain, relieving parkin autoinhibition and nucleating a feed-forward mitophagy cascade that recruits optineurin and NDP52. Recessive loss of function causes early onset Parkinson disease, while kinase-dead and targeting-sequence variants define distinct failure modes. Allele choice follows the question: conditional null for tissue-restricted mitophagy failure, kinase-dead knockin to separate scaffolding from catalysis, and humanized alleles for kinase-activator compound testing. Note that murine Pink1 nulls show respiration and striatal dopamine release deficits without frank nigral degeneration, so pair alleles with mitophagy reporters such as mito-QC or exogenous stressors when neurodegeneration is the endpoint.
What Pink1 mouse models are available?
ingenious targeting laboratory offers 3 distinct Pink1 (PINK1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pink1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pink1 allele types
Knockout, conditional, knockin, humanized, and related paths for Pink1 (human PINK1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pink1 catalog models
3 Pink1 lines with QC documentation and technical support. Pink1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Pink1 mouse model?
We have 3 Pink1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pink1 Mouse Model Types
A Pink1 knockout mouse has the Pink1 gene permanently inactivated, enabling loss of function studies. A Pink1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pink1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Pink1 organized by modification type. Each URL is indexable and matches common search patterns.