Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
DEVELOPING · IN PRODUCTION
Pklr Conditional Knockout, Knockout mouse models
Browse 2 Pklr mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Pklr conditional knockout mouse, Pklr knockout mouse. Request a quote within 24 hours.
Why model Pklr
Two tissue-specific promoters drive Pklr, the mouse ortholog of human PKLR, producing the liver and erythrocyte pyruvate kinase isozymes that catalyze the final, effectively irreversible step of glycolysis, transferring phosphate from phosphoenolpyruvate to ADP under strong allosteric activation by fructose 1,6-bisphosphate and inhibition by ATP and alanine, with the hepatic form additionally suppressed by glucagon-driven phosphorylation. Recessive loss-of-function alleles cause pyruvate kinase deficiency, the commonest enzymatic cause of hereditary nonspherocytic hemolytic anemia, in which ATP depletion in mature erythrocytes that lack mitochondria drives membrane failure and 2,3-bisphosphoglycerate accumulation. Design follows the tissue split: patient-matched missense knockins reproduce the unstable, allosterically impaired enzyme and are the correct substrate for testing activators of the mitapivat class, while conditional nulls separate hepatic from erythroid consequences. The paralogous Pkm locus serves other tissues but does not rescue red cells. Match allele class to hematologic or hepatic glucose endpoints.
What Pklr mouse models are available?
ingenious targeting laboratory offers 2 distinct Pklr (PKLR) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pklr model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pklr allele types
Knockout, conditional, knockin, humanized, and related paths for Pklr (human PKLR). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pklr catalog models
2 Pklr lines with QC documentation and technical support. Pklr floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Pklr-Flox
CKOCKO
These mice carry loxP sites flanking exon 3-9 of Pklr gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Pklr gene.
In production — inquireCKO 253468 - Order
Pklr-KO
KOKO
The exon 3-9 of Pklr gene was deleted to generate Pklr knockout mouse.
In DevelopmentKO 260526
Looking for a Pklr mouse model?
We have 2 Pklr models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pklr Mouse Model Types
A Pklr knockout mouse has the Pklr gene permanently inactivated, enabling loss of function studies. A Pklr conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pklr, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Pklr organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ITL
Send the Pklr line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.