Conventional / global / constitutive KO
●2 Models Available
Plat Conditional Knockout, Knockout mouse models
Browse 2 Plat mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Plat conditional knockout mouse, Plat knockout mouse. Contact us for availability and fast turnaround.
Why model Plat
Plat is the mouse ortholog of human PLAT and encodes tissue-type plasminogen activator, a serine protease built from finger, EGF, two kringle, and catalytic domains that cleaves plasminogen at the Arg-Val activation bond, with fibrin acting as a template that accelerates catalysis several hundred fold. Activity is restrained by PAI-1 (Serpine1) and neuroserpin, circulating enzyme is cleared through LRP1, and in brain tPA additionally processes proBDNF and the NMDA receptor NR1 subunit, linking it to excitotoxicity and barrier opening. Because nulls are viable with only mild fibrin persistence, informative designs combine conditional deletion (endothelial, hepatocyte, or neuronal) with a thrombotic or injury challenge, whereas catalytically dead knockins separate proteolysis from receptor-mediated actions. Plau provides substantial redundancy, so compound Plat Plau animals are needed to expose the full fibrinolytic deficit, and allele class should track the endpoint, whether clot lysis, wound repair, or infarct volume.
What Plat mouse models are available?
ingenious targeting laboratory offers 2 distinct Plat (PLAT) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Plat model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Plat allele types
Knockout, conditional, knockin, humanized, and related paths for Plat (human PLAT). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Plat catalog models
2 Plat lines with QC documentation and technical support. Plat floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Plat (PLAT) from ITL supported projects.
- Apolipoprotein E is a marker of all chondrocytes in the growth plate resting zoneKodama J, Oichi T, Wilkinson KJ, Abzug JM, Kaito T, Enomoto-Iwamoto M, Iwamoto M, Otsuru S. (2025). Bone Res. 1(13): 31
- AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia.Tirado-Gonzalez I, Descot A, Soetopo D, Nevmerzhitskaya A, Schäffer A, Kur IM, Czlonka E, Wachtel C, Tsoukala I, Müller L, Schäfer AL, Weitmann M, Dinse P, Alberto E, Buck MC, Landry JJ, Baying B, Slotta-Huspenina J, Roesler J, Harter PN, Kubasch AS, Meinel J, Elwakeel E, Strack E, Quang CT, Abdel-Wahab O, Schmitz M, Weigert A, Schmid T, Platzbecker U, Benes V, Ghysdael J, Bonig H, Götze KS, Rothlin CV, Ghosh S, Medyouf H. (2021). Cancer Discov 11(11): 2924-2943
- Forkhead box F2 regulation of platelet-derived growth factor and myocardin/serum response factor signaling is essential for intestinal development.Bolte C, Ren X, Tomley T, Ustiyan V, Pradhan A, Hoggatt A, Kalin TV, Herring BP, Kalinichenko VV. (2015). J Biol Chem 290: 7563-7575
- Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice.Min SH, Suzuki A, Stalker TJ, Zhao L, Wang Y, McKennan C, Riese MJ, Guzman JF, Zhang S, Lian L, Joshi R, Meng R, Seeholzer SH, Choi JK, Koretzky G, Marks MS, Abrams CS. (2014). Nat Commun 5: 4691
- Nato3 plays an integral role in dorsoventral patterning of the spinal cord by segregating floor plate/p3 fates via Nkx2.2 suppression and Foxa2 maintenance.Mansour AA, Khazanov-Zisman S, Netser Y, Klar A, Ben-Arie N. (2014). Development 141: 574-584
Looking for a Plat mouse model?
We have 2 Plat models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Plat Mouse Model Types
A Plat knockout mouse has the Plat gene permanently inactivated, enabling loss of function studies. A Plat conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Plat, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Plat organized by modification type. Each URL is indexable and matches common search patterns.