Conventional / global / constitutive KO
●1 Model Available
Pms2 Conditional Knockout mouse model
Browse 1 Pms2 mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Pms2
As the endonuclease-bearing partner of MLH1 in the MutL alpha heterodimer, Pms2 (ortholog of human PMS2) executes the incision step of mismatch repair, using a conserved metal-binding endonuclease motif whose latent nickase activity is licensed by PCNA and RFC to introduce strand-discrimination nicks that direct EXO1 excision of the error-containing nascent strand. Biallelic germline loss causes constitutional mismatch repair deficiency with childhood brain tumors and hematologic malignancy, while monoallelic loss produces Lynch syndrome with microsatellite instability and a hypermutated, immunotherapy-responsive tumor genome. Null mice are viable but cancer prone and male infertile, so conditional alleles matter mainly for lineage-specific tumor initiation, whereas an endonuclease-dead knockin cleanly separates catalytic repair from the damage signaling and apoptotic functions of MutL alpha. Note that MLH1 also partners MLH3 and PMS1 in MutL gamma and MutL beta, so meiotic and somatic repair endpoints should not be treated as interchangeable.
What Pms2 mouse models are available?
ingenious targeting laboratory offers 1 distinct Pms2 (PMS2) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Pms2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Pms2 allele types
Knockout, conditional, knockin, humanized, and related paths for Pms2 (human PMS2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Pms2 catalog models
1 Pms2 line with QC documentation and technical support. Pms2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Pms2-Flox
Conditional KnockoutKO/CKO mice
embryo cryopreservationCKO 200040
Looking for a Pms2 mouse model?
We have 1 Pms2 model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model1
Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Pms2 Mouse Model Types
A Pms2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Pms2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Pms2 organized by modification type. Each URL is indexable and matches common search patterns.