Conventional / global / constitutive KO
●2 Models Available
Rad51 Conditional Knockout, Knockout mouse models
Browse 2 Rad51 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Rad51 conditional knockout mouse, Rad51 knockout mouse. Contact us for availability and fast turnaround.
Why model Rad51
Strand invasion during homologous recombination is executed by RAD51, and Rad51 is the mouse ortholog of human RAD51, encoding the RecA-family recombinase that displaces RPA from resected single-stranded DNA with BRCA2 BRC repeat assistance, polymerizes into an ATP-dependent helical nucleoprotein filament, searches the sister chromatid for homology and catalyzes D-loop formation. Beyond recombination, RAD51 coats and protects stalled replication forks from MRE11 and DNA2 degradation, a function genetically separable from strand exchange. Germline deletion causes very early embryonic lethality that Trp53 loss only partially delays, so conditional nulls with inducible Cre are essential for adult analysis, while dominant-negative Walker motif mutants such as K133R or K133A permit acute, reversible interference with filament turnover. Because the paralogs RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 act as mediators rather than substitutes, they cannot rescue loss; match allele class to whether the endpoint is repair capacity, fork protection or chemosensitivity.
What Rad51 mouse models are available?
ingenious targeting laboratory offers 2 distinct Rad51 (RAD51) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Rad51 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Rad51 allele types
Knockout, conditional, knockin, humanized, and related paths for Rad51 (human RAD51). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Rad51 catalog models
2 Rad51 lines with QC documentation and technical support. Rad51 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Rad51 mouse model?
We have 2 Rad51 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Rad51 Mouse Model Types
A Rad51 knockout mouse has the Rad51 gene permanently inactivated, enabling loss of function studies. A Rad51 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Rad51, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Rad51 organized by modification type. Each URL is indexable and matches common search patterns.