Conventional / global / constitutive KO
●2 Models Available
Rara Conditional Knockout, Knockout mouse models
Browse 2 Rara mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Rara conditional knockout mouse, Rara knockout mouse. Contact us for availability and fast turnaround.
Why model Rara
Rara is the mouse ortholog of human RARA and encodes retinoic acid receptor alpha, a nuclear receptor with AF-1, zinc finger DNA-binding, and ligand-binding domains that heterodimerizes with RXR on direct-repeat retinoic acid response elements, holds targets repressed through NCoR, SMRT, and HDAC complexes when unliganded, and switches to p300 and NCOA coactivators upon all-trans retinoic acid binding. The dominant disease logic is fusion driven, since PML-RARA in acute promyelocytic leukemia converts the receptor into a constitutive repressor that blocks myeloid maturation and is resolved pharmacologically by retinoid-induced degradation. Accordingly, allele choice diverges sharply between conditional nulls for tissue retinoid requirements, dominant-negative or PML-RARA knockins for leukemia modeling, and humanized ligand-binding domains for agonist and degrader pharmacology. Rarb and Rarg compensate extensively, and only compound receptor alleles reproduce full vitamin A deficiency phenotypes, so plan multi-locus conditional genetics with an inducible driver from the outset.
What Rara mouse models are available?
ingenious targeting laboratory offers 2 distinct Rara (RARA) catalog mouse models in the Retinoic acid axis family, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Rara model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Rara allele types
Knockout, conditional, knockin, humanized, and related paths for Rara (human RARA). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Rara catalog models
2 Rara lines with QC documentation and technical support. Rara floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Rara mouse model?
We have 2 Rara models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Rara Mouse Model Types
A Rara knockout mouse has the Rara gene permanently inactivated, enabling loss of function studies. A Rara conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Rara, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Rara organized by modification type. Each URL is indexable and matches common search patterns.