Conventional / global / constitutive KO
●1 Model Available
Ret Conditional Knockout mouse model
Browse 1 Ret mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Ret
Rearranged during transfection kinase, encoded by mouse Ret and orthologous to human RET, is a single-pass receptor tyrosine kinase with four cadherin-like domains and a calcium-binding cysteine-rich region that is activated by GDNF family ligands presented through GFRA1 to GFRA4 co-receptors, triggering phospholipase C gamma, RAS-ERK, and PI3K-AKT signaling essential for enteric neural crest colonization and kidney branching morphogenesis. The mutational logic is strikingly bidirectional: cysteine-rich domain substitutions such as C634R cause multiple endocrine neoplasia type 2A, activation loop M918T causes MEN2B with aggressive medullary thyroid carcinoma, CCDC6-RET and KIF5B-RET fusions drive papillary thyroid and lung adenocarcinoma, and loss-of-function alleles cause Hirschsprung disease. Germline nulls die perinatally with renal agenesis and intestinal aganglionosis, so conditional nulls suit developmental questions while precise hotspot or fusion knockins model tumorigenesis and selpercatinib or pralsetinib response, including resistance substitutions. Match allele to endpoint and use lineage-restricted Cre drivers for thyroid or pulmonary readouts.
What Ret mouse models are available?
ingenious targeting laboratory offers 1 distinct Ret (RET) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ret model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ret allele types
Knockout, conditional, knockin, humanized, and related paths for Ret (human RET). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ret catalog models
1 Ret line with QC documentation and technical support. Ret floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Ret-Flox
Conditional KnockoutKO/CKO mice
sperm cryopreservationCKO 210165
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Ret (RET) from ITL supported projects.
- Mast cell-specific CysLT2 receptor signaling inhibits cysteinyl leukotriene-dependent mast cell activation and type 2 allergic lung inflammationNagai J, Hastings MM, Nishida A, Majumdar S, Zaleski K, Marshall SA, Lin J, Saliman MAS, Tani Y, Murakami Y, Feng C, Perniss A, Wong C, Bankova LG, Inoue A, Barrett NA, Boyce JA. (2026). Cell Rep. 1(45): 116758.
- Jchain-diphtheria toxin receptor mice allow for depletion of antibody-secreting cells and analysis of differentiation kineticsPioli KT, Ritchie M, Haq H, Pioli PD. (2025). iScience 12(28):113946
- Conditional deletion of miR-204 and miR-211 in murine retinal pigment epithelium results in retinal degenerationDu SW, Komirisetty R, Lewandowski D, Choi EH, Panas D, Suh S, Tabaka M, Radu RA, Palczewski K. (2024). J Biol Chem 300(6): 107344
- Neuromedin B-expressing neurons in the retrotrapezoid nucleus regulate respiratory homeostasis and promote stable breathing in adult mice.Souza G, Stornetta DS, Shi Y, Lim E, Berry FE, Bayliss DA, Abbott SBG. (2023). J Neurosci 43(30): 5501-5520
- Characterization of olfactomedin 4+ cells in prostate and urethral-tube epithelium during murine postnatal development and in adult mice.Li H, Chaitankar V, Cui L, Chen W, Chin K, Zhu J, Liu W, Rodgers GP. (2023). Sci Rep 13(1): 10290
Looking for a Ret mouse model?
We have 1 Ret model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
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Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ret Mouse Model Types
A Ret conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ret, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ret organized by modification type. Each URL is indexable and matches common search patterns.