Runx1 Overexpression / Safe Harbor Mouse
Since 1998, ingenious targeting laboratory has delivered 2,800+ projects with 100% germline transmission guarantee and 800+ peer reviewed publications.
Runx1 is a common request for overexpression / safe harbor mouse models. ingenious targeting laboratory designs and delivers the line to your study specification with documented milestones.
Get a Quote in 24 HoursWhat Runx1 Overexpression / Safe Harbor mouse models are available?
ingenious targeting laboratory designs and generates Runx1 overexpression / safe harbor mouse models to your specification. Quotes return in about 24 hours with documented germline transmission and strict United States QC guidelines.
Scientific design
Runx1 is a well studied locus in mouse genetics. Allele design follows your phenotype goals and what the published landscape already shows for this gene.
3 existing alleles are indexed for Runx1, including 1 conditional, including 2 knockout. Where the published set lacks the modification you need, ingenious targeting laboratory builds that allele with documented germline transmission.
Targeted overexpression places your transgene at a safe harbor or Rosa26 locus with defined copy number and expression control. That avoids random integration position effects caught during pre germline screening.
Quotes return in about 24 hours with milestones, pricing, and options for cryo or live dispatch.
What researchers say
“ingenious targeting laboratory delivered exactly the floxed allele we designed, with clear milestones and germline confirmed founders.”
“The team translated our humanization requirements into a knockin strategy we could breed and phenotype on schedule.”
“Clear communication on allele design and germline transmission made our conditional knockout program straightforward to execute.”
Selected publications
- Functional characterization of cooperating MGA mutations in RUNX1::RUNX1T1 acute myeloid leukemia
- Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia
- CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation
FAQ
What Runx1 Overexpression / Safe Harbor mouse models are available?
When Runx1 Overexpression / Safe Harbor lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Runx1 knockout embryonic lethal in mice?
It depends on background and allele design. Some Runx1 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Runx1 animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Runx1?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.