Conventional / global / constitutive KO
●3 Models Available
Runx1 Conditional Knockout, Knockout mouse models
Browse 3 Runx1 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Runx1 conditional knockout mouse, Runx1 knockout mouse. Request a quote within 24 hours.
Why model Runx1
Definitive hematopoiesis requires Runx1, the mouse ortholog of human RUNX1 (AML1), a Runt domain transcription factor that heterodimerizes with CBFB to raise DNA affinity at core enhancer TGTGGT motifs and recruits either coactivators such as CBP or corepressors including NCOR-HDAC and GFI1 machinery, governing endothelial to hematopoietic transition, megakaryocyte maturation, and lymphoid development. Disease alleles are mechanistically diverse: germline heterozygous mutations cause familial platelet disorder with predisposition to myeloid malignancy, somatic point mutations cluster in the Runt domain in myelodysplastic syndrome and acute myeloid leukemia, and translocations generate RUNX1-RUNX1T1 or ETV6-RUNX1 chimeras that convert the factor into a dominant repressor. Because germline nulls die around midgestation lacking definitive hematopoietic stem cells, conditional nulls with Vav1-cre or Mx1-cre are essential, while knockin of Runt domain point mutants or endogenous fusion alleles addresses dominant negative mechanism. Paralogs Runx2 and Runx3 share CBFB and DNA motifs, so lineage compensation should be tested explicitly.
What Runx1 mouse models are available?
ingenious targeting laboratory offers 3 distinct Runx1 (RUNX1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Runx1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Runx1 allele types
Knockout, conditional, knockin, humanized, and related paths for Runx1 (human RUNX1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Runx1 catalog models
3 Runx1 lines with QC documentation and technical support. Runx1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Runx1 (RUNX1) from ITL supported projects.
- Functional characterization of cooperating MGA mutations in RUNX1::RUNX1T1 acute myeloid leukemiaThomas ME, Qi W, Walsh MP, Ma J, Westover T, Abdelhamed S, Ezzell LJ, Rolle C, Xiong E, Rosikiewicz W, Xu B, Loughran AJ, Pruett-Miller SM, Janke LJ, Klco JM. (2024). Leukemia 5(38): 991-1002
- Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid LeukemiaKlco J, Iii MT, Qi W, Walsh M, Ma J, Westover T, Abdelhamed S, Ezzell L, Rolle C, Xiong E, Rosikiewicz W, Xu B, Pruett-Miller S, Loughran A, Janke L. (2023). Res Sq
- CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiationHsu J, Huang HT, Lee CT, Choudhuri A, Wilson NK, Abraham BJ, Moignard V, Kucinski I, Yu S, Hyde RK, Tober J, Cai X, Li Y, Guo Y, Yang S, Superdock M, Trompouki E, Calero-Nieto FJ, Ghamari A, Jiang J, Gao P, Gao L, Nguyen V, Robertson AL, Durand EM, glKathrein KL, Aifantis I, Gerber SA, Tong W, Tan K, Cantor AB, Zhou Y, Liu PP, Young RA, Göttgens B, Speck NA, Zon LI. (2020). Proc Natl Acad Sci U S A 117(38): 23626-23635
Looking for a Runx1 mouse model?
We have 3 Runx1 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
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Model Types
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Quote Turnaround
Included
QC Documentation
About Runx1 Mouse Model Types
A Runx1 knockout mouse has the Runx1 gene permanently inactivated, enabling loss of function studies. A Runx1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Runx1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Runx1 organized by modification type. Each URL is indexable and matches common search patterns.