Conventional / global / constitutive KO
●1 Model Available
READY TO SHIP!
DEVELOPING
Rxra Conditional Knockout mouse model
Browse 1 Rxra mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Rxra
Rxra, the mouse ortholog of human RXRA, encodes retinoid X receptor alpha, the obligate heterodimer partner for RAR, PPAR, LXR, FXR, VDR, and NR4A receptors, which makes its deletion a simultaneous collapse of multiple nuclear receptor axes rather than a single pathway lesion. As the permissive partner it contributes DNA binding at direct repeats and coregulator recruitment, and it is the pharmacological target of rexinoids such as bexarotene. Germline nulls die in mid to late gestation with myocardial thinning, ventricular hypoplasia, and placental defects, so conditional alleles with Alb-Cre, K14-Cre, LysM-Cre, or Mx1-Cre are essential to reach adult metabolic, epidermal, and myeloid endpoints. Point knockins that selectively disable ligand binding or the heterodimer interface separate structural partnering from ligand-dependent activation, and humanized ligand-binding domains support rexinoid pharmacology. Rxrb and Rxrg substitute in several tissues, so compound conditional deletion is often required before assigning a phenotype to Rxra.
What Rxra mouse models are available?
ingenious targeting laboratory offers 1 distinct Rxra (RXRA) catalog mouse model in the Retinoic acid axis family, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Rxra model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Rxra allele types
Knockout, conditional, knockin, humanized, and related paths for Rxra (human RXRA). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Rxra catalog models
1 Rxra line with QC documentation and technical support. Rxra floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Rxra-Flox
CKOCKO
These mice carry loxP sites flanking exon3-4 of Rxra gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Rxra gene.
In DevelopmentCKO 263481
Looking for a Rxra mouse model?
We have 1 Rxra model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model1
Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Rxra Mouse Model Types
A Rxra conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Rxra, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Rxra organized by modification type. Each URL is indexable and matches common search patterns.
Related Gene Targets
Breed this line with ITL
Send the Rxra line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.