Conventional / global / constitutive KO
●1 Model Available
READY TO SHIP!
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Serpind1 Knockout mouse model
Browse 1 Serpind1 mouse model including knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Serpind1
Serpind1 is the mouse ortholog of human SERPIND1 and encodes heparin cofactor II, a plasma serpin that inhibits thrombin through a Leu-Ser reactive center and is accelerated up to a thousand fold by dermatan sulfate, which binds a basic surface and releases an acidic N-terminal extension that then engages thrombin anion-binding exosite II. This dermatan sulfate dependence localizes activity to the subendothelial matrix rather than the luminal heparan sulfate compartment served by antithrombin, giving heparin cofactor II a distinct role after vessel injury. Nulls are viable and fertile with normal baseline hemostasis but show accelerated thrombus formation after photochemical or ferric chloride carotid injury, so germline deletion is informative while hepatocyte conditional alleles pin the source. Glycosaminoglycan-binding or reactive center loop knockins separate cofactor dependence from intrinsic inhibition. Since Serpinc1 dominates fluid-phase thrombin control, interpret accordingly and align alleles with arterial injury or restenosis endpoints.
What Serpind1 mouse models are available?
ingenious targeting laboratory offers 1 distinct Serpind1 (SERPIND1) catalog mouse model, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Serpind1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Serpind1 allele types
Knockout, conditional, knockin, humanized, and related paths for Serpind1 (human SERPIND1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Serpind1 catalog models
1 Serpind1 line with QC documentation and technical support.
- Order
Serpind1-KO
KOKO
The exon3 of Serpind1 gene was deleted to generate Serpind1 knockout mouse.
In DevelopmentKO 262797
Looking for a Serpind1 mouse model?
We have 1 Serpind1 model available — including Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Serpind1 Mouse Model Types
A Serpind1 knockout mouse has the Serpind1 gene permanently inactivated, enabling loss of function studies.
Modifications available
Jump to catalog backed pages for Serpind1 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ITL
Send the Serpind1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.