Conventional / global / constitutive KO
●1 Model Available
READY TO SHIP!
EMBRYO
Setd2 Conditional Knockout mouse model
Browse 1 Setd2 mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Setd2
Setd2 encodes the mouse ortholog of human SETD2, the sole methyltransferase that trimethylates histone H3 lysine 36 in mammals, coupling to transcription through an SRI domain that docks on the phosphorylated C-terminal domain of elongating RNA polymerase II and thereby governing co-transcriptional splicing, MSH6-dependent mismatch repair recruitment, homologous recombination, and suppression of cryptic intragenic initiation; it additionally methylates alpha tubulin K40 during mitosis. Truncating mutations are enriched in clear cell renal carcinoma, where 3p loss removes SETD2 together with VHL, BAP1, and PBRM1, and also recur in leukemia, glioma, and pediatric high grade astrocytoma, making loss of function with H3K36me3 depletion the defining event. Germline nulls die in midgestation from vascular remodeling failure, so conditional nulls are required, ideally with Pax8-cre or Ksp-cadherin-cre plus concurrent Vhl deletion to reconstruct renal tumor genetics. Catalytically dead SET knockins separate methyltransferase output from scaffold roles, and no paralog restores H3K36me3, so single-locus deletion is interpretable.
What Setd2 mouse models are available?
ingenious targeting laboratory offers 1 distinct Setd2 (SETD2) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Setd2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Setd2 allele types
Knockout, conditional, knockin, humanized, and related paths for Setd2 (human SETD2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Setd2 catalog models
1 Setd2 line with QC documentation and technical support. Setd2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Setd2-Flox(2)
CKOCKO
These mice carry loxP sites flanking exon 3 of Setd2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Setd2 gene.While Setd2-Flox mice(Stock No.KO 00126）have been pulled from shelves for some reasons.
Embryo CryopreservedCKO 190069
Looking for a Setd2 mouse model?
We have 1 Setd2 model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Setd2 Mouse Model Types
A Setd2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Setd2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Setd2 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Setd2 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.