Conventional / global / constitutive KO
●1 Model Available
Setd2 Conditional Knockout mouse model
Browse 1 Setd2 mouse model including conditional knockout variants — in stock and ready to ship from ingenious targeting laboratory. Request a quote within 24 hours.
Why model Setd2
Setd2 encodes the mouse ortholog of human SETD2, the sole methyltransferase that trimethylates histone H3 lysine 36 in mammals, coupling to transcription through an SRI domain that docks on the phosphorylated C-terminal domain of elongating RNA polymerase II and thereby governing co-transcriptional splicing, MSH6-dependent mismatch repair recruitment, homologous recombination, and suppression of cryptic intragenic initiation; it additionally methylates alpha tubulin K40 during mitosis. Truncating mutations are enriched in clear cell renal carcinoma, where 3p loss removes SETD2 together with VHL, BAP1, and PBRM1, and also recur in leukemia, glioma, and pediatric high grade astrocytoma, making loss of function with H3K36me3 depletion the defining event. Germline nulls die in midgestation from vascular remodeling failure, so conditional nulls are required, ideally with Pax8-cre or Ksp-cadherin-cre plus concurrent Vhl deletion to reconstruct renal tumor genetics. Catalytically dead SET knockins separate methyltransferase output from scaffold roles, and no paralog restores H3K36me3, so single-locus deletion is interpretable.
What Setd2 mouse models are available?
ingenious targeting laboratory offers 1 distinct Setd2 (SETD2) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Setd2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Setd2 allele types
Knockout, conditional, knockin, humanized, and related paths for Setd2 (human SETD2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Setd2 catalog models
1 Setd2 line with QC documentation and technical support. Setd2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Setd2-Flox(2)
Conditional KnockoutKO/CKO mice
liveCKO 190069
Looking for a Setd2 mouse model?
We have 1 Setd2 model in stock — including Conditional Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Setd2 Mouse Model Types
A Setd2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Setd2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Setd2 organized by modification type. Each URL is indexable and matches common search patterns.