Conventional / global / constitutive KO
●3 Models Available
Sigmar1 Conditional Knockout, Knockout mouse models
Browse 3 Sigmar1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Sigmar1 conditional knockout mouse, Sigmar1 knockout mouse. Contact us for availability and fast turnaround.
Why model Sigmar1
At mitochondria-associated ER membranes, the product of mouse Sigmar1, ortholog of human SIGMAR1, functions as a ligand-operated chaperone rather than a classical receptor, forming an ER membrane protein that associates with BiP and, upon agonist binding or calcium depletion, dissociates to stabilize IP3 receptor type 3 and sustain calcium transfer from ER to mitochondria. Sigma-1 receptor also chaperones ion channels, modulates the unfolded protein response through IRE1, and translocates to the nuclear envelope and plasma membrane. Recessive E102Q causes juvenile ALS16 and other variants cause distal hereditary motor neuropathy, with loss of contact site integrity, calcium dysregulation, and impaired autophagic flux as proposed mechanisms. Because Sigmar1 knockout mice are viable with late-onset motor deficits, both conditional null and patient knockin alleles are practical, and humanization is attractive given active agonist pharmacology such as pridopidine. Select motor neuron Cre drivers when contact site integrity and neuromuscular junction endpoints matter.
What Sigmar1 mouse models are available?
ingenious targeting laboratory offers 3 distinct Sigmar1 (SIGMAR1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Sigmar1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Sigmar1 allele types
Knockout, conditional, knockin, humanized, and related paths for Sigmar1 (human SIGMAR1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Sigmar1 catalog models
3 Sigmar1 lines with QC documentation and technical support. Sigmar1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Sigmar1 mouse model?
We have 3 Sigmar1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Sigmar1 Mouse Model Types
A Sigmar1 knockout mouse has the Sigmar1 gene permanently inactivated, enabling loss of function studies. A Sigmar1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Sigmar1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Sigmar1 organized by modification type. Each URL is indexable and matches common search patterns.