Conventional / global / constitutive KO
●4 Models Available
Slc17a6 Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Slc17a6 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Slc17a6 conditional knockout mouse, Slc17a6 knockin mouse, Slc17a6 knockout mouse. Request a quote within 24 hours.
Why model Slc17a6
Vesicular glutamate loading in subcortical circuits is carried out by Slc17a6, the mouse ortholog of human SLC17A6, encoding VGLUT2, a twelve-transmembrane SLC17 family transporter that uses the vacuolar ATPase-generated proton electrochemical gradient, predominantly its membrane potential component, to concentrate glutamate into synaptic vesicles, with biphasic allosteric chloride dependence and a distinct phosphate transport activity. VGLUT2 dominates thalamus, hypothalamus, brainstem, and spinal cord and marks glutamatergic identity in dopaminergic and other neuromodulatory neurons that co-release glutamate. Constitutive nulls die at birth from respiratory failure, so conditional floxed alleles are the standard tool, widely used to remove glutamate co-release from specific populations with Cre lines such as Slc6a3-Cre or Th-Cre. Knockin reporter or Cre-expressing alleles at the locus are equally common for circuit access. Because Slc17a7 and Slc17a8 occupy largely non-overlapping territories, true compensation is limited; match allele to identity, co-release, or quantal size endpoints.
What Slc17a6 mouse models are available?
ingenious targeting laboratory offers 4 distinct Slc17a6 (SLC17A6) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Slc17a6 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Slc17a6 allele types
Knockout, conditional, knockin, humanized, and related paths for Slc17a6 (human SLC17A6). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Slc17a6 catalog models
4 Slc17a6 lines with QC documentation and technical support. Slc17a6 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Slc17a6 mouse model?
We have 4 Slc17a6 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Slc17a6 Mouse Model Types
A Slc17a6 knockout mouse has the Slc17a6 gene permanently inactivated, enabling loss of function studies. A Slc17a6 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Slc17a6, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Slc17a6 knockin models carry a precisely inserted sequence at the Slc17a6 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Slc17a6 organized by modification type. Each URL is indexable and matches common search patterns.