Conventional / global / constitutive KO
●2 Models Available
Slc17a8 Knockin, Knockout mouse models
Browse 2 Slc17a8 mouse models including knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Slc17a8 knockin mouse, Slc17a8 knockout mouse. Request a quote within 24 hours.
Why model Slc17a8
Restricted but functionally distinctive, Slc17a8 encodes the mouse ortholog of human SLC17A8, VGLUT3, an SLC17 vesicular glutamate transporter expressed not in canonical glutamatergic neurons but in cholinergic striatal interneurons, serotonergic raphe neurons, a subset of GABAergic cortical interneurons, cochlear inner hair cells, and some dorsal root ganglion neurons, where it enables glutamate co-release and vesicular synergy that enhances loading of the primary transmitter. Dominant SLC17A8 variants cause autosomal dominant nonsyndromic deafness DFNA25, and knockout mice are profoundly deaf from failed inner hair cell transmission while also showing altered anxiety, cocaine response, and audiogenic seizure susceptibility. Because the null is viable, constitutive deletion is feasible, but conditional alleles are preferred when separating cochlear from central contributions, and knockin Cre alleles give access to co-releasing populations. Redundancy with Slc17a6 and Slc17a7 is minimal in these cell types, so match allele class directly to auditory, striatal, or serotonergic endpoints.
What Slc17a8 mouse models are available?
ingenious targeting laboratory offers 2 distinct Slc17a8 (SLC17A8) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Slc17a8 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
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Slc17a8 allele types
Knockout, conditional, knockin, humanized, and related paths for Slc17a8 (human SLC17A8). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Looking for a Slc17a8 mouse model?
We have 2 Slc17a8 models in stock — including Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Slc17a8 Mouse Model Types
A Slc17a8 knockout mouse has the Slc17a8 gene permanently inactivated, enabling loss of function studies. Slc17a8 knockin models carry a precisely inserted sequence at the Slc17a8 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Slc17a8 organized by modification type. Each URL is indexable and matches common search patterns.