Conventional / global / constitutive KO
●2 Models Available
Slc1a3 Knockin, Knockout mouse models
Browse 2 Slc1a3 mouse models including knockin, knockout variants from ingenious targeting laboratory. Available as Slc1a3 knockin mouse, Slc1a3 knockout mouse. Contact us for availability and fast turnaround.
Why model Slc1a3
GLAST, encoded by mouse Slc1a3 and orthologous to human SLC1A3, is the EAAT1 glutamate transporter enriched in Bergmann glia, retinal Muller cells, cochlear supporting cells, and cortical astrocytes, operating as a trimeric elevator transporter that couples glutamate influx to three sodium ions and one proton with potassium countertransport plus an anion conductance contributing to glial membrane behavior. Dominant missense variants, notably P290R, cause episodic ataxia type 6 by combining reduced uptake with an enhanced anion current, a mechanism that a simple null cannot reproduce. Slc1a3 knockout mice are viable but show cerebellar motor incoordination, heightened susceptibility to excitotoxic injury, and retinal dysfunction. Allele choice therefore forks between conditional null for regional uptake capacity questions and patient knockins for the dominant channelopathy mechanism. Because Slc1a2 carries most forebrain uptake, cerebellar and retinal endpoints are the most informative, and inducible glial CreERT2 drivers avoid developmental confounds.
What Slc1a3 mouse models are available?
ingenious targeting laboratory offers 2 distinct Slc1a3 (SLC1A3) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Slc1a3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Slc1a3 allele types
Knockout, conditional, knockin, humanized, and related paths for Slc1a3 (human SLC1A3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Looking for a Slc1a3 mouse model?
We have 2 Slc1a3 models available — including Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Slc1a3 Mouse Model Types
A Slc1a3 knockout mouse has the Slc1a3 gene permanently inactivated, enabling loss of function studies. Slc1a3 knockin models carry a precisely inserted sequence at the Slc1a3 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Slc1a3 organized by modification type. Each URL is indexable and matches common search patterns.