Conventional / global / constitutive KO
●2 Models Available
Slc6a3 Knockin, Knockout mouse models
Browse 2 Slc6a3 mouse models including knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Slc6a3 knockin mouse, Slc6a3 knockout mouse. Request a quote within 24 hours.
Why model Slc6a3
Dopamine clearance depends on Slc6a3, the mouse ortholog of human SLC6A3, encoding the dopamine transporter, an SLC6 sodium and chloride coupled symporter with LeuT architecture concentrated on midbrain dopaminergic terminals in striatum, where it sets extracellular dopamine lifetime, supports vesicular refilling, serves as the primary molecular target of cocaine, amphetamine, and methylphenidate, and provides the route of MPP+ entry that confers selective nigral vulnerability. Biallelic loss of function causes dopamine transporter deficiency syndrome with infantile parkinsonism-dystonia, and common variation has been linked to ADHD phenotypes. Slc6a3 knockout mice are viable but hyperdopaminergic, hyperactive, growth retarded, and insensitive to cocaine reward, and the locus is also the standard site for DAT-Cre and DAT-CreERT2 knockin drivers, which must be chosen carefully because some cassettes reduce transporter expression. Match allele class to endpoint, using patient missense knockins for trafficking-defect mechanisms and humanization for inhibitor pharmacology.
What Slc6a3 mouse models are available?
ingenious targeting laboratory offers 2 distinct Slc6a3 (SLC6A3) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Slc6a3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Slc6a3 allele types
Knockout, conditional, knockin, humanized, and related paths for Slc6a3 (human SLC6A3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Looking for a Slc6a3 mouse model?
We have 2 Slc6a3 models in stock — including Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Slc6a3 Mouse Model Types
A Slc6a3 knockout mouse has the Slc6a3 gene permanently inactivated, enabling loss of function studies. Slc6a3 knockin models carry a precisely inserted sequence at the Slc6a3 locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Slc6a3 organized by modification type. Each URL is indexable and matches common search patterns.