What Sod1 Conditional Knockout mouse models are available?

When Sod1 Conditional Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.

Is Sod1 knockout embryonic lethal in mice?

It depends on background and allele design. Some Sod1 germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.

Which Cre driver is best for experiments?

Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.

Do you ship live Sod1 animals?

When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.

How do I request a quote for Sod1?

Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.

●4 Models Available

Sod1 Conditional Knockout, Knockin, Knockout mouse models

Browse 4 Sod1 mouse models including conditional knockout, knockin, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Sod1 conditional knockout mouse, Sod1 knockin mouse, Sod1 knockout mouse. Request a quote within 24 hours.

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Why model Sod1

Cytosolic superoxide detoxification is carried out by Sod1, the mouse ortholog of human SOD1, encoding copper and zinc superoxide dismutase, a beta-barrel homodimer stabilized by an intrasubunit Cys57 to Cys146 disulfide and metallated by the copper chaperone CCS, which dismutates superoxide to hydrogen peroxide and oxygen in cytosol and mitochondrial intermembrane space. More than 180 dominant SOD1 mutations, including G93A, G85R, and A4V, cause ALS1 through gain of toxic function involving misfolding, aberrant metal handling, and aggregation rather than loss of dismutase activity, a distinction confirmed because Sod1 knockout mice do not develop motor neuron disease but instead show distal axonopathy, hearing loss, muscle atrophy, and oxidative damage. Allele design therefore favors patient missense knockins at the endogenous locus over overexpression transgenes when physiologic dosage matters, with humanized alleles required for tofersen-class antisense oligonucleotide testing and conditional nulls reserved for cell-autonomy questions.

What Sod1 mouse models are available?

ingenious targeting laboratory offers 4 distinct Sod1 (SOD1) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.

Model availability, allele class options, and quality control standards
Model Availability	Allele Class Options	Quality Control Standards
4 Ready Catalog Lines	Conditional Knockout (cKO)	Documented Germline Transmission
Custom Model Generation	Constitutive Knockout (KO)	Strict United States QC Guidelines
Advanced Modifications	Humanized, Knockin, Transgenic	Cryo or Live Dispatch Options

Quality Control: Documented Germline Transmission
Quality Control: Strict United States QC Guidelines
Quality Control: Cryo or Live Dispatch Options

Sod1 model types

PathAvailability

Knockout
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Conditional knockout
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Knockin
View catalog
Humanized
Request a quote
Transgenic / overexpression
Request a quote

Prefer the order form? Order. Need an allele that is not listed? Request a quote.

Sod1 allele types

Knockout, conditional, knockin, humanized, and related paths for Sod1 (human SOD1). Catalog lines ship when inventory exists. Everything else is a generation quote.

Knockout

Conventional / global / constitutive KO

Conditional KO (floxed / loxP)

Inducible conditional KO (CreER / tet)

Tissue specific KO

Specify tissue or Cre driver on quote

Knockout first (tm1a / IKMC)

Convertible floxed allele pathway

Double / compound KO

Multi allele / compound knockout project

Large scale / BAC deletion

BAC scale deletion or targeting

Knockin

Point mutation KI

cDNA KI

Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)

Tag KI (FLAG, HA, Myc, V5)

Conditional KI (e.g. Rosa26 LSL)

LSL or conditional expression knockin

Gene replacement KI

Humanized

Full gene replacement

Partial / domain humanized

Domain or partial humanization scope

Immune checkpoint humanized

Checkpoint IO humanization when gene is a checkpoint target

Single humanized

Double / multi humanized

Multi humanized / combination IO project

Transgenic

Random integration transgenic

Safe harbor (ROSA26, HPRT, H11, Col1a1)

Overexpression transgenic

BAC transgenic

BAC transgenic or large fragment insert

Cre / recombinase

Constitutive Cre driver

Inducible Cre (CreER / tet)

Tamoxifen or dox inducible Cre

Dual recombinase (Cre+Dre / Cre+Flp)

Dual recombinase breeding scheme

Flp driver

Flp or FRT derivative allele pairing

Reporter

Reporter knockin (gene specific)

Standalone reporter catalog (lineage tracing, constitutive, dual reporter)

Catalog reporter lines not tied to a single gene allele

Species / background

Rat KO / KI / transgenic

Specify rat on quote

Rabbit models

Specify rabbit on quote

C57BL/6 (B6J / B6N)

Background substrain on quote

BALB/c

129, NOD, NSG, FVB, CD1, DBA/2

Background strain on quote

Mouse Models

Two paths. One scientific team.

Search 14,774+ study ready strains, or commission the exact knockout, knockin, or humanized model your program requires.

Ready to ship

Search 14,774 strains. Many ship from live colonies.

Browse by gene, model type, or therapeutic area. Live colonies available for many top requested knockouts, knockins, and humanized lines.

Trp53Tumor suppressor, knockout & knockin Brca1Breast cancer model, multiple alleles Rosa26Safe harbor for reporters & cassettes

Browse Full Catalog

Model generation

Need a knockout, knockin, or humanized line?

The same U.S. scientific team designs and delivers your allele when it is not on the shelf. 100% germline transmission guarantee.

Conventional and conditional knockouts
Point mutation and humanized knockins
2,800+ models generated since 1998

Request a Quote Explore model generation services

Available Sod1 catalog models

4 Sod1 lines with QC documentation and technical support. Sod1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.

Sod1-Flox
Conditional Knockout
KO/CKO mice, disease model mice
sperm cryopreservationCKO 231249
Order
Sod1-G94A
Knockin
point mutantion mice
In production — inquireKI 232083
Order
Sod1-KO(2)
Knockout
KO/CKO mice
sperm cryopreservationKO 235025
Order
Sod1-KO
Knockout
KO/CKO mice, disease model mice
sperm cryopreservationKO 190151
Order

Selected publications from ingenious targeting laboratory

Peer reviewed work involving Sod1 (SOD1) from ITL supported projects.

Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS.Rosenblum LT, Shamamandri-Markandaiah S, Ghosh B, Foran E, Lepore AC, Pasinelli P, Trotti D. (2017). Exp Neurol292: 145-153

View all ITL publications

Looking for a Sod1 mouse model?

We have 4 Sod1 models in stock — including Conditional Knockout, Knockin, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.

Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.

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Models Available

Model Types

24 hrs

Quote Turnaround

Included

QC Documentation

About Sod1 Mouse Model Types

A Sod1 knockout mouse has the Sod1 gene permanently inactivated, enabling loss of function studies. A Sod1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Sod1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Sod1 knockin models carry a precisely inserted sequence at the Sod1 locus, useful for reporter, tag, or humanization studies.

Knockout Mouse Models Conditional Knockout Mouse Models Knockin Mouse Models Mouse Model Generation Services

Modifications available

Jump to catalog backed pages for Sod1 organized by modification type. Each URL is indexable and matches common search patterns.

Sod1 Conditional Knockout Sod1 Knockin Sod1 Knockout Sod1 cDNA Knockin Sod1 Epitope Tag Knockin Sod1 Humanized Sod1 Inducible Knockout Sod1 Overexpression / Safe Harbor Sod1 Reporter

Tissue-specific options

Catalog backed tissue and driver restricted routes for Sod1.

neural Sod1 conditional knockout

Related Gene Targets

SOD1 Sod2 Sod3