Conventional / global / constitutive KO
●3 Models Available
Sqstm1 Conditional Knockout, Knockout mouse models
Browse 3 Sqstm1 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Sqstm1 conditional knockout mouse, Sqstm1 knockout mouse. Request a quote within 24 hours.
Why model Sqstm1
p62, the product of mouse Sqstm1 and ortholog of human SQSTM1, is a multidomain signaling adaptor and selective autophagy receptor built from an N-terminal PB1 domain that self-oligomerizes and binds NBR1 and atypical PKCs, a ZZ zinc finger, a TRAF6 binding region, an LC3-interacting region, a KEAP1-interacting region, and a C-terminal UBA domain that captures ubiquitinated cargo. By bridging polyubiquitinated substrates to LC3 on the phagophore, p62 drives aggrephagy and mitophagy, while sequestering KEAP1 to activate NRF2 antioxidant transcription and scaffolding NF-kappaB signaling. SQSTM1 mutations, mostly clustered in the UBA domain, cause Paget disease of bone, ALS with frontotemporal dementia, and distal myopathy. Constitutive knockout mice are viable but develop mature-onset obesity, insulin resistance, and age-dependent neurodegeneration, so metabolic confounds argue for conditional deletion with neuronal or microglial Cre drivers, while UBA or LIR point knockins cleanly separate cargo binding from NRF2 and NF-kappaB functions.
What Sqstm1 mouse models are available?
ingenious targeting laboratory offers 3 distinct Sqstm1 (SQSTM1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Sqstm1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Sqstm1 allele types
Knockout, conditional, knockin, humanized, and related paths for Sqstm1 (human SQSTM1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Sqstm1 catalog models
3 Sqstm1 lines with QC documentation and technical support. Sqstm1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Sqstm1 mouse model?
We have 3 Sqstm1 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Sqstm1 Mouse Model Types
A Sqstm1 knockout mouse has the Sqstm1 gene permanently inactivated, enabling loss of function studies. A Sqstm1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Sqstm1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Sqstm1 organized by modification type. Each URL is indexable and matches common search patterns.