Conventional / global / constitutive KO
●3 Models Available
READY TO SHIP!
SPERM
Sqstm1 Conditional Knockout, Knockout mouse models
Browse 3 Sqstm1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Sqstm1 conditional knockout mouse, Sqstm1 knockout mouse. Contact us for availability and fast turnaround.
Why model Sqstm1
p62, the product of mouse Sqstm1 and ortholog of human SQSTM1, is a multidomain signaling adaptor and selective autophagy receptor built from an N-terminal PB1 domain that self-oligomerizes and binds NBR1 and atypical PKCs, a ZZ zinc finger, a TRAF6 binding region, an LC3-interacting region, a KEAP1-interacting region, and a C-terminal UBA domain that captures ubiquitinated cargo. By bridging polyubiquitinated substrates to LC3 on the phagophore, p62 drives aggrephagy and mitophagy, while sequestering KEAP1 to activate NRF2 antioxidant transcription and scaffolding NF-kappaB signaling. SQSTM1 mutations, mostly clustered in the UBA domain, cause Paget disease of bone, ALS with frontotemporal dementia, and distal myopathy. Constitutive knockout mice are viable but develop mature-onset obesity, insulin resistance, and age-dependent neurodegeneration, so metabolic confounds argue for conditional deletion with neuronal or microglial Cre drivers, while UBA or LIR point knockins cleanly separate cargo binding from NRF2 and NF-kappaB functions.
What Sqstm1 mouse models are available?
ingenious targeting laboratory offers 3 distinct Sqstm1 (SQSTM1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Sqstm1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Sqstm1 allele types
Knockout, conditional, knockin, humanized, and related paths for Sqstm1 (human SQSTM1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Sqstm1 catalog models
3 Sqstm1 lines with QC documentation and technical support. Sqstm1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Sqstm1-Flox
CKOCKO
These strains carry loxP sites flanking exon 1 of Sqstm1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Sqstm1 gene.
Sperm CryopreservedCKO 232165 - Order
Sqstm1-KO
KOKO
Exon 2-4 of Sqstm1 gene was deleted to generate Sqstm1 knockout mice.
Sperm CryopreservedKO 225094 - Order
Sqstm1-KO(2)
KOKO
The exon 1 of Sqstm1 gene was deleted to generate Sqstm1 knockout mouse.
Sperm CryopreservedKO 235065
Looking for a Sqstm1 mouse model?
We have 3 Sqstm1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Sqstm1 Mouse Model Types
A Sqstm1 knockout mouse has the Sqstm1 gene permanently inactivated, enabling loss of function studies. A Sqstm1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Sqstm1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Sqstm1 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Sqstm1 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.