Conventional / global / constitutive KO
●2 Models Available
Stat5b Conditional Knockout, Knockout mouse models
Browse 2 Stat5b mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Stat5b conditional knockout mouse, Stat5b knockout mouse. Contact us for availability and fast turnaround.
Why model Stat5b
Encoded within the same tandem locus as Stat5a, Stat5b is the ortholog of human STAT5B and transduces growth hormone receptor signaling through JAK2, binding GAS elements to induce Igf1, Socs2 and Igfals and thereby setting somatic growth, while also mediating IL-2 receptor signaling required for regulatory T cell Foxp3 expression and NK cell homeostasis. Human loss-of-function mutations produce growth hormone insensitivity with severe short stature accompanied by immune dysregulation and eczema, whereas activating substitutions such as N642H drive T cell and NK cell leukemias, giving two knockin designs with opposite biology. Selective deletion in mouse abolishes male-pattern hepatic gene expression and reduces body growth. Given the extreme sequence identity and physical linkage with Stat5a, distinguish single-gene from dual-locus floxed alleles at the design stage, and pair conditional deletion with a hematopoietic or hepatocyte Cre driver matched to the intended endpoint.
What Stat5b mouse models are available?
ingenious targeting laboratory offers 2 distinct Stat5b (STAT5B) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Stat5b model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Stat5b allele types
Knockout, conditional, knockin, humanized, and related paths for Stat5b (human STAT5B). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Stat5b catalog models
2 Stat5b lines with QC documentation and technical support. Stat5b floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Stat5b mouse model?
We have 2 Stat5b models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Stat5b Mouse Model Types
A Stat5b knockout mouse has the Stat5b gene permanently inactivated, enabling loss of function studies. A Stat5b conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Stat5b, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Stat5b organized by modification type. Each URL is indexable and matches common search patterns.