Conventional / global / constitutive KO
●2 Models Available
Tab3 Conditional Knockout, Knockout mouse models
Browse 2 Tab3 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Tab3 conditional knockout mouse, Tab3 knockout mouse. Contact us for availability and fast turnaround.
Why model Tab3
Functioning as the paralog that explains many negative results at the Tab2 locus, Tab3 is the mouse ortholog of human TAB3 and encodes an NZF-containing adaptor that likewise binds K63-linked polyubiquitin and the TAK1 kinase domain to support IL-1, TNF, and TLR driven TAK1 activation, with preferences dictated by receptor context and cell type rather than by a wholly distinct mechanism. Its NZF domain reads ubiquitin chains through a different surface than TAB2, and the two proteins occupy TAK1 in mutually exclusive complexes, which is why acute loss of one is buffered. Germline nulls are viable and largely unremarkable, so informative designs are compound conditional alleles with Tab2, or NZF-inactivating knockins that separate ubiquitin recognition from TAK1 binding within an otherwise intact complex. Given genuine redundancy, never treat a single Tab3 knockout as a TAK1 pathway test, and anchor compound genetics to cytokine transcription, hepatocyte survival, or tumor NF-kB endpoints using validated Cre lines.
What Tab3 mouse models are available?
ingenious targeting laboratory offers 2 distinct Tab3 (TAB3) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tab3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tab3 allele types
Knockout, conditional, knockin, humanized, and related paths for Tab3 (human TAB3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tab3 catalog models
2 Tab3 lines with QC documentation and technical support. Tab3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Tab3 mouse model?
We have 2 Tab3 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tab3 Mouse Model Types
A Tab3 knockout mouse has the Tab3 gene permanently inactivated, enabling loss of function studies. A Tab3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tab3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tab3 organized by modification type. Each URL is indexable and matches common search patterns.