Conventional / global / constitutive KO
●4 Models Available
READY TO SHIP!
SPERM
Tert Conditional Knockout, Knockin, Knockout mouse models
Browse 4 Tert mouse models including conditional knockout, knockin, knockout variants from ingenious targeting laboratory. Available as Tert conditional knockout mouse, Tert knockin mouse, Tert knockout mouse. Contact us for availability and fast turnaround.
Why model Tert
Tert encodes the mouse ortholog of human TERT, the catalytic reverse transcriptase subunit of telomerase, which assembles with the noncoding RNA template Terc plus dyskerin, NOP10, NHP2, and GAR1 and is recruited to chromosome ends by TPP1 to add telomere repeats, using an N-terminal essential domain, an RNA binding domain, and a canonical reverse transcriptase fold. Human cancer activates TERT chiefly through recurrent promoter mutations at positions 124 and 146 upstream of the start codon, which create de novo GABP ETS binding sites and reactivate transcription in melanoma, glioblastoma, bladder cancer, and hepatocellular carcinoma, whereas germline loss-of-function alleles cause dyskeratosis congenita, aplastic anemia, and pulmonary fibrosis. A critical species caveat governs design: laboratory mice carry very long telomeres and tolerate Tert deletion for several generations, so nulls model attrition only after successive intercrossing or on a Terc-deficient background. Promoter-humanized or hTERT knockin alleles are therefore the appropriate choice for promoter mutation biology and telomerase-directed therapeutics.
What Tert mouse models are available?
ingenious targeting laboratory offers 4 distinct Tert (TERT) catalog mouse models, featuring conditional knockout, standard knockout, and knockin. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 4 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tert model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tert allele types
Knockout, conditional, knockin, humanized, and related paths for Tert (human TERT). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tert catalog models
4 Tert lines with QC documentation and technical support. Tert floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Tert-Flox
CKOCKO
These strains carry loxP sites flanking exon 1-2 of Tert gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tert gene.
Sperm CryopreservedCKO 241947 - Order
Tert-CreERT2-2A-EGFP
KICre/Dre Toolbox, Fluorescent Model
A CreERT2-2A-GFP-WPRE-PA expression cassette was knocked into the Telt gene start codon site by homologous recombination.
Sperm CryopreservedKI 18037 - Order
Tert-KO(2)
KOKO
The exon 1-2 of Tert gene was deleted to generate Tert knockout mouse.
Sperm CryopreservedKO 250253 - Order
Tert-KO
KOKO
The exon 2-10 of Tert gene was deleted to generate Tert knockout mouse.
Sperm CryopreservedKO 240173
Looking for a Tert mouse model?
We have 4 Tert models available — including Conditional Knockout, Knockin, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model4
Models Available
3
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tert Mouse Model Types
A Tert knockout mouse has the Tert gene permanently inactivated, enabling loss of function studies. A Tert conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tert, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints. Tert knockin models carry a precisely inserted sequence at the Tert locus, useful for reporter, tag, or humanization studies.
Modifications available
Jump to catalog backed pages for Tert organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Tert line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.