Conventional / global / constitutive KO
●3 Models Available
Tia1 Conditional Knockout, Knockout mouse models
Browse 3 Tia1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Tia1 conditional knockout mouse, Tia1 knockout mouse. Contact us for availability and fast turnaround.
Why model Tia1
Stress granule nucleation depends on Tia1, the mouse ortholog of human TIA1, encoding a nucleocytoplasmic RNA binding protein with three RRM domains and a C-terminal prion-like low complexity domain that drives liquid-liquid phase separation. TIA1 binds U-rich sequences to promote alternative splicing and, upon eIF2alpha phosphorylation during integrated stress response activation, recruits stalled preinitiation complexes into cytoplasmic stress granules while repressing translation of specific transcripts. Missense mutations within the low complexity domain, notably P362L and E384K, alter granule dynamics and delay disassembly, causing Welander distal myopathy and contributing to ALS and frontotemporal dementia with TDP-43 pathology. Allele logic follows: patient missense knockins at the endogenous locus model altered phase behavior, whereas conditional null tests granule-independent splicing roles. Tia1 nulls show partial embryonic lethality with viable survivors, and the paralog Tial1 provides genuine functional overlap, so compound alleles are advisable when granule assembly itself is the endpoint.
What Tia1 mouse models are available?
ingenious targeting laboratory offers 3 distinct Tia1 (TIA1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tia1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tia1 allele types
Knockout, conditional, knockin, humanized, and related paths for Tia1 (human TIA1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tia1 catalog models
3 Tia1 lines with QC documentation and technical support. Tia1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Tia1 mouse model?
We have 3 Tia1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tia1 Mouse Model Types
A Tia1 knockout mouse has the Tia1 gene permanently inactivated, enabling loss of function studies. A Tia1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tia1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tia1 organized by modification type. Each URL is indexable and matches common search patterns.