Tnfrsf1b Knockout mouse models
Tnfrsf1b is the mouse ortholog of human TNFRSF1B and encodes TNFR2 (p75), which binds membrane-anchored TNF preferentially and, lacking a death domain, signals instead through TRAF1, TRAF2, and cIAP1 to activate canonical and non-canonical NF-kB, PI3K, and AKT, thereby delivering survival and proliferative rather than cytotoxic instructions. Because TNFR2 sequesters TRAF2 and cIAP away from TNFR1 complexes, it also modulates TNFR1-driven death, and its restricted expression on regulatory T cells, myeloid-derived suppressor cells, endothelium, oligodendrocyte progenitors, and cardiomyocytes underlies interest in agonists for tolerance and repair and antagonists for Treg depletion in tumors. Nulls are viable, so germline deletion is tractable, conditional alleles distinguish Treg-intrinsic costimulation from tissue-protective signaling, and ectodomain humanization is mandatory for agonist or blocking antibodies that fail to cross-react. Since Tnfrsf1a shares the ligand, interpret with compound receptor genetics and align alleles to Treg expansion, graft tolerance, or remyelination endpoints.
A conventional Tnfrsf1b knockout removes gene function in all cells that inherit the allele. It is a proven first pass for target validation when redundancy is low.
What Tnfrsf1b Knockout mouse models are available?
ingenious targeting laboratory offers 1 distinct Tnfrsf1b knockout catalog mouse model. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
Catalog table
| Model | Type | Category | Availability | Catalog # | Action |
|---|---|---|---|---|---|
| Tnfrsf1b-KO | Knockout | KO/CKO mice | live | KO 200541 | Inquire |
Why this approach
A conventional knockout answers whether the gene is required broadly. When your target tissue is the organ of interest, a global null can still be informative if viability is acceptable and you want the simplest genotype. If the null is harsh, a floxed allele with a regional Cre is the safer long term platform.
Pricing and quotes
The Tnfrsf1b Knockout lines listed above are catalog models. Send us the catalog number and our team confirms current availability, pricing, and whether the line ships cryopreserved or live.
If your study needs a Tnfrsf1b allele configuration that is not listed above, our scientific team designs and generates it. Model generation quotes return in about twenty four hours with project milestones and pricing.
FAQ
What Tnfrsf1b Knockout mouse models are available?
When Tnfrsf1b Knockout lines are in catalog, we ship from inventory. If your configuration is not listed, we design the allele to order. Common paths include conditional knockout, constitutive knockout, humanized, knockin, and transgenic options, with documented germline transmission and United States QC.
Is Tnfrsf1b knockout embryonic lethal in mice?
It depends on background and allele design. Some Tnfrsf1b germline knockouts are viable. Others need conditional alleles or mixed backgrounds. We review publications and our own experience, then recommend floxed versus null before you commit.
Which Cre driver is best for experiments?
Driver choice depends on onset timing, recombination efficiency, and known leak. We map your organ and cell type to a short list of proven Cre lines, then talk through reporter crosses and controls. We favor drivers with strong community validation for your tissue.
Do you ship live Tnfrsf1b animals?
When catalog lines are live, we ship with health certificates and QC documentation. If your exact combo is not listed, we quote a generation project with cryo or live dispatch depending on cohort timing and geography.
How do I request a quote for Tnfrsf1b?
Use the catalog inquire buttons or the request quote form. Include your allele goal, Cre plan if any, strain background, and cohort size. A PhD led team responds with pricing, milestones, and the fastest path to experimental animals.