Conventional / global / constitutive KO
●2 Models Available
Tnfrsf1b Conditional Knockout, Knockout mouse models
Browse 2 Tnfrsf1b mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Tnfrsf1b conditional knockout mouse, Tnfrsf1b knockout mouse. Request a quote within 24 hours.
Why model Tnfrsf1b
Tnfrsf1b is the mouse ortholog of human TNFRSF1B and encodes TNFR2 (p75), which binds membrane-anchored TNF preferentially and, lacking a death domain, signals instead through TRAF1, TRAF2, and cIAP1 to activate canonical and non-canonical NF-kB, PI3K, and AKT, thereby delivering survival and proliferative rather than cytotoxic instructions. Because TNFR2 sequesters TRAF2 and cIAP away from TNFR1 complexes, it also modulates TNFR1-driven death, and its restricted expression on regulatory T cells, myeloid-derived suppressor cells, endothelium, oligodendrocyte progenitors, and cardiomyocytes underlies interest in agonists for tolerance and repair and antagonists for Treg depletion in tumors. Nulls are viable, so germline deletion is tractable, conditional alleles distinguish Treg-intrinsic costimulation from tissue-protective signaling, and ectodomain humanization is mandatory for agonist or blocking antibodies that fail to cross-react. Since Tnfrsf1a shares the ligand, interpret with compound receptor genetics and align alleles to Treg expansion, graft tolerance, or remyelination endpoints.
What Tnfrsf1b mouse models are available?
ingenious targeting laboratory offers 2 distinct Tnfrsf1b (TNFRSF1B) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tnfrsf1b model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tnfrsf1b allele types
Knockout, conditional, knockin, humanized, and related paths for Tnfrsf1b (human TNFRSF1B). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Looking for a Tnfrsf1b mouse model?
We have 2 Tnfrsf1b models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tnfrsf1b Mouse Model Types
A Tnfrsf1b knockout mouse has the Tnfrsf1b gene permanently inactivated, enabling loss of function studies. A Tnfrsf1b conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tnfrsf1b, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tnfrsf1b organized by modification type. Each URL is indexable and matches common search patterns.