Conventional / global / constitutive KO
●3 Models Available
READY TO SHIP!
SPERM · DEVELOPING · IN PRODUCTION
Tyk2 Conditional Knockout, Knockout mouse models
Browse 3 Tyk2 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Tyk2 conditional knockout mouse, Tyk2 knockout mouse. Request a quote within 24 hours.
Why model Tyk2
Tyk2, the mouse ortholog of human TYK2, encodes a JAK-family kinase whose FERM and SH2-like modules dock receptor boxes, whose JH2 pseudokinase domain autoinhibits catalysis, and whose kinase domain phosphorylates STAT1, STAT2, STAT3, and STAT4 downstream of IFNAR1, IL12RB1, and IL10RA, placing it at the center of type I interferon, IL-12, IL-23, and IL-10 responses. Human genetics frames the design: complete deficiency causes mycobacterial and viral susceptibility, while the common P1104A hypomorph is protective against psoriasis and inflammatory bowel disease, so a knockin of that exact substitution models allosteric partial inhibition far better than a null does. Kinase-dead alleles further separate catalytic output from scaffolding, and humanized JH2 or full-locus replacement is effectively required for deucravacitinib-class pseudokinase binders that do not engage the mouse domain. JAK1 is an obligate heterodimeric partner, not a redundant substitute, so anticipate compound genetics only when interrogating receptor-specific pairing.
What Tyk2 mouse models are available?
ingenious targeting laboratory offers 3 distinct Tyk2 (TYK2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Tyk2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Tyk2 allele types
Knockout, conditional, knockin, humanized, and related paths for Tyk2 (human TYK2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Tyk2 catalog models
3 Tyk2 lines with QC documentation and technical support. Tyk2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Tyk2-Flox
CKOCKO
These mice carry loxP sites flanking exon 4-6 of Tyk2 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tyk2 gene.
In production — inquireCKO 254097 - Order
Tyk2-KO(2)
KOKO
The exon 4-6 of Tyk2 gene was deleted to generate Tyk2 knockout mouse.
In DevelopmentKO 261738 - Order
Tyk2-KO
KOKO, Disease Model
Exon 4 of Tyk2 gene was deleted to generate Tyk2 knockout mice.
Sperm CryopreservedKO 201976
Looking for a Tyk2 mouse model?
We have 3 Tyk2 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Tyk2 Mouse Model Types
A Tyk2 knockout mouse has the Tyk2 gene permanently inactivated, enabling loss of function studies. A Tyk2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Tyk2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Tyk2 organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Tyk2 line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.