Conventional / global / constitutive KO
●2 Models Available
Vcp Conditional Knockout, Knockout mouse models
Browse 2 Vcp mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Vcp conditional knockout mouse, Vcp knockout mouse. Contact us for availability and fast turnaround.
Why model Vcp
The AAA+ ATPase p97, encoded by mouse Vcp and orthologous to human VCP, is a homohexameric segregase with an N domain plus tandem D1 and D2 ATPase rings that threads ubiquitinated substrates through its central pore, extracting them from membranes, chromatin, and multiprotein complexes. Cofactors assign function: UFD1 and NPL4 direct ER-associated degradation and ribosome quality control, p47 supports membrane fusion, and UBXD1 and others govern lysosomal and mitochondrial quality control plus autophagosome maturation. Dominant missense mutations, mostly at the N to D1 interface such as R155H and R191Q, cause multisystem proteinopathy, namely inclusion body myopathy with Paget disease and frontotemporal dementia, plus ALS14, by increasing ATPase activity and altering cofactor binding rather than ablating function. Constitutive Vcp null is embryonic lethal while heterozygous nulls are largely normal, so patient knockins at the endogenous locus are the correct allele; use conditional alleles with muscle or neuronal Cre for tissue-specific proteostasis endpoints.
What Vcp mouse models are available?
ingenious targeting laboratory offers 2 distinct Vcp (VCP) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Vcp model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Vcp allele types
Knockout, conditional, knockin, humanized, and related paths for Vcp (human VCP). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Vcp catalog models
2 Vcp lines with QC documentation and technical support. Vcp floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Vcp (VCP) from ITL supported projects.
- VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy.Cheng C, Weiss L, Leinonen H, Shmara A, Yin HZ, Ton T, Do A, Lee J, Ta L, Mohanty E, Vargas J, Weiss J, Palczewski K, Kimonis V. (2022). J Transl Med 20(1): 21
- VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy.Cheng C, Weiss L, Leinonen H, Shmara A, Yin HZ, Ton T, Do A, Lee J, Ta L, Mohanty E, Vargas J, Weiss J, Palczewski K, Kimonis V. (2022). J Transl Med 20(1): 21
- Exon skipping technology in VCP diseaseKimonis V, Nalbandian A. (2018). US Patent No.10093932B2
- Global gene expression profiling in R155H knock-in murine model of VCP disease.Nalbandian A, Ghimbovschi S, Wang Z, Knoblach S, Llewellyn KJ, Vesa J, Hoffman EP, Kimonis VE. (2015). Clin Transl Sci 8: 8-16
- A progressive translational mouse model of human valosin-containing protein disease: the VCP(R155H/+) mouse.Nalbandian A, Llewellyn KJ, Badadani M, Yin HZ, Nguyen C, Katheria V, Watts G, Mukherjee J, Vesa J, Caiozzo V, Mozaffar T, Weiss JH, Kimonis VE. (2013). Muscle Nerve 47: 260-270
Looking for a Vcp mouse model?
We have 2 Vcp models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Vcp Mouse Model Types
A Vcp knockout mouse has the Vcp gene permanently inactivated, enabling loss of function studies. A Vcp conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Vcp, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Vcp organized by modification type. Each URL is indexable and matches common search patterns.