Humanized mouse services for drug development.
Pricing & 24h quote.
We have built humanized mouse models since 1998. Drug-target humanization, immune checkpoint humanization (PD1, PDL1, CTLA4, LAG3, TIM3), and complete gene replacement. 800+ peer-reviewed publications. 100% germline transmission guarantee.
Custom humanized mice — fixed-fee quote in 24 hours.
Pricing scales with humanization strategy (drug-target replacement, immune checkpoint, complete gene replacement), allele complexity, and timeline. Free scientific consultation included.
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How much do humanized mice cost?
Pricing scales with humanization strategy (drug-target replacement, immune checkpoint humanization, complete gene replacement), allele complexity, and delivery timeline. Add your work email above to get current pricing or request a fixed-fee quote in 24 hours after a free scientific consultation. We deliver germline-confirmed founders.
How long does it take to build a humanized mouse?
Typical humanized mouse projects deliver germline-confirmed founders in 9–14 months depending on humanization strategy, ES cell vs CRISPR approach, and validation requirements. Many off-the-shelf humanized models in our catalog ship from live colonies in weeks.
What humanization strategies do you offer?
Three strategies: (1) drug-target humanization — replace the gene encoding your therapeutic target so mouse models become predictive of human pharmacology, (2) immune checkpoint humanization (PD1, PDL1, CTLA4, LAG3, TIM3) — for checkpoint inhibitor efficacy testing, and (3) complete gene replacement — replace the entire mouse gene with the human ortholog for human-specific biology studies.
Do you have ready-to-ship humanized mice?
Yes. Our catalog includes 14,774+ ready-to-ship genetically engineered mouse models, including humanized lines such as hSCAP, hCFH, PD1 humanized, and PDL1 humanized. Search the catalog by gene to see live-colony availability before commissioning a custom build.
Do you guarantee germline transmission?
Yes. Every custom humanized mouse project from ingenious targeting laboratory carries a 100% germline transmission guarantee. We deliver germline-confirmed founders or we keep working until we do.
Four humanized mouse services. One vendor.
Immune Checkpoint Humanization
Replace mouse immune checkpoint genes with human orthologs for therapeutic antibody efficacy testing. Single, double, and combination checkpoint humanization.
Learn more →Drug-Target Humanization
Humanize the gene encoding your therapeutic target so mouse models become predictive of human pharmacology and efficacy.
Learn more →Complete Gene Replacement
Replace the entire mouse gene with the human ortholog at the endogenous locus. Best for studying human-specific biology.
Learn more →Off-the-Shelf Humanized Lines
Skip the build entirely. Browse our catalog of ready-to-ship humanized mouse models from live colonies.
Learn more →Want the full technical breakdown?
See our complete humanized mouse models page with strategy comparisons, validation methods, and case studies.
See Full Humanized Mouse Models Page