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Study Design & Applications

Tissue-Specific Knockout (Examples: Liver, Neuron)

A genetically engineered mouse model in which a target gene is selectively deleted or inactivated in a specific tissue or cell type, rather than throughout the entire organism. Typically relies on the Cre-LoxP recombination system.

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Overview

A tissue-specific knockout is a genetically engineered mouse model in which a target gene is selectively deleted or inactivated in a specific tissue or cell type, rather than throughout the entire organism. This typically relies on the Cre-LoxP recombination system.

Frequently Asked Questions

What are common tissue-specific Cre drivers?

Albumin-Cre for liver, Nestin-Cre for neurons, Myh6-Cre for heart, and LysM-Cre for myeloid cells are commonly used.

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Related Terms

Cre Driver Line (Tissue-Specific Cre)

A mouse line that expresses Cre recombinase from a promoter specific to certain tissues, cell types, or developmental stages, enabling targeted genomic recombination only in those cells.

Conditional Knockout (cKO) Mouse Models

A genetically engineered mouse in which a specific gene can be selectively inactivated in chosen tissues, cell types, or developmental stages—enabling precise studies of gene function while avoiding embryonic lethality or systemic effects.

Temporal Control (Induction Windows, Dosing)

The activation or deactivation of a genetic modification at a specific time or during a defined developmental window. This strategy allows researchers to study gene function dynamically and distinguish developmental effects from later ones.

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