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Recombination Systems & Tools

Tet-On / Tet-Off (Tetracycline Systems)

Tetracycline-responsive transcription systems that regulate gene expression reversibly through doxycycline administration, allowing dose- and time-dependent control of transgene activity.

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Overview

Tet-On and Tet-Off are tetracycline-responsive transcription systems that regulate gene expression reversibly through doxycycline administration, allowing dose- and time-dependent control of transgene activity.

Frequently Asked Questions

What is the difference between Tet-On and Tet-Off?

Tet-On activates gene expression in the presence of doxycycline; Tet-Off activates in its absence.

Is expression reversible?

Yes. Gene expression can be toggled on or off by administering or withdrawing doxycycline.

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Related Terms

Inducible Allele (Cre-ER Systems)

A genetically engineered version of a gene that can be activated or deleted at a specific time by an external stimulus. The most widely used approach is the Cre-ER system, allowing researchers to precisely control the timing of gene modification in vivo.

Temporal Control (Induction Windows, Dosing)

The activation or deactivation of a genetic modification at a specific time or during a defined developmental window. This strategy allows researchers to study gene function dynamically and distinguish developmental effects from later ones.

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Temporal Control (Induction Windows, Dosing)View All TermsTissue-Specific Knockout (Examples: Liver, Neuron)

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