Conventional / global / constitutive KO
●2 Models Available
READY TO SHIP!
SPERM
Ang Conditional Knockout, Knockout mouse models
Browse 2 Ang mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Ang conditional knockout mouse, Ang knockout mouse. Contact us for availability and fast turnaround.
Why model Ang
Angiogenin, the product of mouse Ang and ortholog of human ANG (also called RNASE5), is a secreted RNase A superfamily ribonuclease whose His13, Lys40, His114 catalytic triad supports weak but obligatory cleavage of tRNA anticodon loops, generating stress-induced tiRNA fragments that displace eIF4G and reprogram translation initiation. Under basal conditions the enzyme is clamped by cytosolic RNH1, and during stress it is internalized by motor neurons through syndecan and neuropilin-1 before translocating to the nucleolus to sustain 45S rRNA transcription. Amyotrophic lateral sclerosis and frontotemporal dementia alleles such as K40I and C39W are catalytically hypomorphic, so a conditional null addresses cell-autonomous requirement while a patient point knockin tests whether diminished ribonucleolytic output alone drives motor neuron vulnerability, and humanization enables recombinant protein dosing work. Because the mouse locus is a tandem cluster spanning Ang2 through Ang6, single-gene deletion is buffered; pair Chat-Cre or Gfap-Cre conditionals with neuromuscular junction and survival endpoints.
What Ang mouse models are available?
ingenious targeting laboratory offers 2 distinct Ang (ANG) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Ang model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Ang allele types
Knockout, conditional, knockin, humanized, and related paths for Ang (human ANG). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Ang catalog models
2 Ang lines with QC documentation and technical support. Ang floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Ang-Flox
CKOCKO
These mice carry loxP sites flanking exon 2 of Ang gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ang gene.
Sperm CryopreservedCKO 253110 - Order
Ang-KO
KOKO
Exon 2 of Ang gene was deleted to generate Ang knockout mice.
Sperm CryopreservedKO 201392
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Ang (ANG) from ingenious supported projects.
- Clarifying the molecular mechanisms underlying the lethal in vitro cellular effects and mild organismal phenotype of SOD1 lossWang Y, Noë A, Truong-Ong L, Hekimi S. (2026). Sci Rep. Online ahead of print
- PD-1 regulates latent effector differentiation of thymic cytotoxic CD8+ T cellsMao Z, Hirdler JB, Gicobi JK, Ding L, Maynes MA, Hsu MA, Dellacecca ER, Zhang W, Teske JJ, Li Y, Liew AY, Zhao G, Ting AT, Shapiro VM, Lucien-Matteoni F, Borges da Silva H, Billadeau DD, Dong H. (2026). Nat Commun. Online ahead of print
- Nitric oxide drives proteomic diversity through alternative splicingSchindler JC, Seth P, Hausladen A, Chan ER, Yang J, Qin J, Qian Z, Seth D, Lundberg K, Luna JM, Premont RT, Stamler JS. (2026). Mol Cell. 12 (86): P2345-2340.E9
- Mitochondrial L-2-hydroxyglutarate is a physiological signalling metaboliteChakrabarty RP, Van Vranken JG, Aoi Y, Poor TA, McElroy GS, Vasan K, Soliman SHA, Iwanaszko M, Grant RA, Howard BC, Reczek CR, Chandel AD, Kahl M, Xu Z, Helmin KA, Jin Q, Wang D, Gao P, Blum JLE, Sebo ZL, Yue F, Ma YC, Davidson SM, Gygi SP, Weinberg SE, Singer BD, Han S, Shilatifard A, Chandel NS. (2026). Nature . Online ahead of print.
- S100A4-lineage cells contribute modestly to angiotensin II-mediated thoracic aortic aneurysms through angiotensin II type 1a receptor in miceIto S, Chen JZ, Howatt DA, Moorleghen JJ, Lu HS, Daugherty A, Sawada H. (2026). PLoS One 5(21): e0348111.
Looking for a Ang mouse model?
We have 2 Ang models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Ang Mouse Model Types
A Ang knockout mouse has the Ang gene permanently inactivated, enabling loss of function studies. A Ang conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Ang, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Ang organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ingenious targeting laboratory
Send the Ang line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.