Conventional / global / constitutive KO
●1 Model Available
Atp5f1a Conditional Knockout mouse model
Browse 1 Atp5f1a mouse model including conditional knockout variants from ingenious targeting laboratory. Contact us for availability and fast turnaround.
Why model Atp5f1a
Oxidative phosphorylation stalls without Atp5f1a, the mouse ortholog of human ATP5F1A, which encodes the alpha subunit present in three copies within the alpha3beta3 hexamer forming the soluble F1 catalytic head of mitochondrial ATP synthase. Alpha subunits provide noncatalytic nucleotide sites and the structural walls against which the rotating gamma central stalk imposes sequential conformational changes on catalytic beta subunits, so alpha is indispensable for rotary coupling rather than merely accessory. De novo dominant and recessive human variants cause encephalopathy, hypotonia, and lactic acidosis with reduced complex V holoenzyme, phenotypes a targeted missense knockin reproduces far better than deletion. No nuclear paralog covers this function, and complete loss of complex V catalysis is incompatible with development, so conditional floxed alleles are mandatory for postnatal work. Combine Ckmm-Cre, Myh6-MerCreMer, or Nes-Cre with blue native PAGE, oligomycin sensitive respiration, and cristae ultrastructure as endpoints.
What Atp5f1a mouse models are available?
ingenious targeting laboratory offers 1 distinct Atp5f1a (ATP5F1A) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Atp5f1a model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Atp5f1a allele types
Knockout, conditional, knockin, humanized, and related paths for Atp5f1a (human ATP5F1A). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Atp5f1a catalog models
1 Atp5f1a line with QC documentation and technical support. Atp5f1a floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Atp5f1a-Flox
Conditional KnockoutKO/CKO mice
sperm cryopreservationCKO 241632
Looking for a Atp5f1a mouse model?
We have 1 Atp5f1a model available — including Conditional Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Atp5f1a Mouse Model Types
A Atp5f1a conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Atp5f1a, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Atp5f1a organized by modification type. Each URL is indexable and matches common search patterns.