Conventional / global / constitutive KO
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READY TO SHIP!
IN PRODUCTION
Atp5f1c Conditional Knockout mouse model
Browse 1 Atp5f1c mouse model including conditional knockout variants — in stock and ready to ship from ingenious targeting laboratory. Request a quote within 24 hours.
Why model Atp5f1c
Rotary coupling in complex V depends on Atp5f1c, the mouse ortholog of human ATP5F1C, encoding the gamma subunit that forms the central stalk with delta and epsilon, inserts into the alpha3beta3 barrel, and converts torque generated by proton driven c-ring rotation into conformational cycling of the catalytic beta subunits. The transcript undergoes tissue specific alternative splicing that swaps carboxy terminal sequence between muscle and liver forms, a feature making isoform selective knockins uniquely informative here. Recessive human variants reduce holoenzyme assembly and present with mitochondrial encephalomyopathy and 3-methylglutaconic aciduria, so a patient substitution knockin captures partial function while a conditional null defines absolute tissue requirement. No redundant nuclear gene compensates, so lineage restricted floxed alleles with Ckmm-Cre, Alb-Cre, or Rosa26-CreER are the practical route. Choose readouts reporting coupling directly, including oligomycin sensitive oxygen consumption, ATP synthesis in permeabilized fibers, and blue native resolution of F1 subcomplexes.
What Atp5f1c mouse models are available?
ingenious targeting laboratory offers 1 distinct Atp5f1c (ATP5F1C) catalog mouse model, featuring conditional knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 1 Ready Catalog Line | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) on request |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Atp5f1c model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Atp5f1c allele types
Knockout, conditional, knockin, humanized, and related paths for Atp5f1c (human ATP5F1C). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO
Inducible conditional KO
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI
Tag KI
Conditional KI
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Targeted Transgenic
Safe harbor
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre
Tamoxifen or dox inducible Cre
Dual recombinase
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Gene specific reporter knockin
Standalone reporter catalog
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Atp5f1c catalog models
1 Atp5f1c line with QC documentation and technical support. Atp5f1c floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
- Order
Atp5f1c-Flox
CKOCKO
These mice carry loxP sites flanking exon2-3 of Atp5f1c gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Atp5f1c gene.
In production — inquireCKO 261182
Looking for a Atp5f1c mouse model?
We have 1 Atp5f1c model in stock — including Conditional Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
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Models Available
1
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Atp5f1c Mouse Model Types
A Atp5f1c conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Atp5f1c, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Atp5f1c organized by modification type. Each URL is indexable and matches common search patterns.
Breed this line with ITL
Send the Atp5f1c line to a U.S. barrier facility for colony maintenance, cohort production, and complex breeding schemes through mouse breeding services.