Conventional / global / constitutive KO
●3 Models Available
Bak1 Conditional Knockout, Knockout mouse models
Browse 3 Bak1 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Bak1 conditional knockout mouse, Bak1 knockout mouse. Contact us for availability and fast turnaround.
Why model Bak1
Bak1 encodes BAK, the mouse ortholog of human BAK1 and one of two obligate multidomain effectors of mitochondrial outer membrane permeabilization. Unlike BAX, BAK resides constitutively in the outer membrane anchored by its alpha9 transmembrane helix, and activation begins when a BH3-only ligand such as BID, BIM, or PUMA transiently engages the canonical hydrophobic groove, triggering separation of the core and latch domains, exposure of the alpha6 dimerization interface, and assembly of BH3-in-groove homodimers that oligomerize into lipidic pores releasing cytochrome c and SMAC. Because Bax provides near-complete functional overlap, single Bak1 nulls are viable and largely unremarkable, and only Bax Bak1 double deficiency reveals the full phenotype, including persistent interdigital webbing, imperforate vaginal closure, accumulated neurons, and frequent perinatal death. Design accordingly: conditional Bak1 flox alleles combined with Bax flox and a tissue-restricted Cre for apoptosis-resistance studies, or groove mutants when distinguishing activation from effector pore formation during BH3 mimetic pharmacology.
What Bak1 mouse models are available?
ingenious targeting laboratory offers 3 distinct Bak1 (BAK1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 3 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Bak1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Bak1 allele types
Knockout, conditional, knockin, humanized, and related paths for Bak1 (human BAK1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Bak1 catalog models
3 Bak1 lines with QC documentation and technical support. Bak1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Bak1 mouse model?
We have 3 Bak1 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model3
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Bak1 Mouse Model Types
A Bak1 knockout mouse has the Bak1 gene permanently inactivated, enabling loss of function studies. A Bak1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Bak1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Bak1 organized by modification type. Each URL is indexable and matches common search patterns.