Conventional / global / constitutive KO
●2 Models Available
Bax Conditional Knockout, Knockout mouse models
Browse 2 Bax mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Bax conditional knockout mouse, Bax knockout mouse. Request a quote within 24 hours.
Why model Bax
Mouse Bax, ortholog of human BAX, encodes the cytosolic counterpart to BAK and executes mitochondrial outer membrane permeabilization once activated by upstream ligands. In healthy cells BAX cycles between cytosol and mitochondria, its alpha9 helix sequestered in its own hydrophobic groove and continuously retrotranslocated by BCL2L1 and MCL1, so commitment requires BH3-only activators (BID, BIM, PUMA) to engage either the canonical groove or the alpha1 to alpha6 rear site, driving conformational opening, membrane insertion, symmetric BH3-in-groove dimers, and pore formation upstream of APAF1 apoptosome assembly. Since BAK1 is largely redundant, informative genetics almost always requires compound alleles, and germline Bax Bak1 double nulls are frequently perinatal lethal with retained interdigital webs and expanded neural progenitors. Conditional Bax flox stocks paired with Bak1 flox and a lineage-restricted Cre are therefore the practical route, with non-functional point knockins reserved for questions about oligomerization mechanism rather than absolute apoptotic capacity.
What Bax mouse models are available?
ingenious targeting laboratory offers 2 distinct Bax (BAX) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Bax model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Bax allele types
Knockout, conditional, knockin, humanized, and related paths for Bax (human BAX). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Selected publications from ingenious targeting laboratory
Peer reviewed work involving Bax (BAX) from ITL supported projects.
- Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1Khor B, Conway KL, Omar AS, Biton M, Haber AL, Rogel N, Baxt LA, Begun J, Kuballa P, Gagnon JD, Lassen KG, Regev A, Xavier RJ. (2019). J Immunol 203(7): 1820-1829
- Mouse transmembrane BAX inhibitor motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system.Nielsen JA, Chambers MA, Romm E, Lee LY, Berndt JA, Hudson LD. (2011). Mol Cell Biochem 357: 73-81
Looking for a Bax mouse model?
We have 2 Bax models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Bax Mouse Model Types
A Bax knockout mouse has the Bax gene permanently inactivated, enabling loss of function studies. A Bax conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Bax, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Bax organized by modification type. Each URL is indexable and matches common search patterns.