Conventional / global / constitutive KO
●2 Models Available
Bbc3 Conditional Knockout, Knockout mouse models
Browse 2 Bbc3 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Bbc3 conditional knockout mouse, Bbc3 knockout mouse. Contact us for availability and fast turnaround.
Why model Bbc3
Bbc3, ortholog of human BBC3, encodes PUMA, a BH3-only protein that is among the most direct transcriptional outputs of p53 and therefore the principal transducer of DNA damage, oncogene stress, and glucocorticoid or cytokine withdrawal into mitochondrial apoptosis. PUMA is unusual among BH3-only members in binding all antiapoptotic relatives, BCL2, BCL2L1, BCL2L2, MCL1, and BCL2A1, with high affinity, so it both liberates and directly activates BAX and BAK; p53-independent induction via FOXO3A and CHOP extends its reach to trophic factor loss and ER stress. Nulls are viable and fertile but show marked resistance of thymocytes and hematopoietic progenitors to irradiation, and phenotypes are frequently blunted because Pmaip1 (NOXA), Bid, and Bcl2l11 cover overlapping stress inputs, making compound alleles necessary. Choose a conditional null when asking whether a tissue requires PUMA for damage-induced deletion, and pair it with p53 pathway alleles when tumor latency or therapy response is the endpoint.
What Bbc3 mouse models are available?
ingenious targeting laboratory offers 2 distinct Bbc3 (BBC3) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Bbc3 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Bbc3 allele types
Knockout, conditional, knockin, humanized, and related paths for Bbc3 (human BBC3). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Bbc3 catalog models
2 Bbc3 lines with QC documentation and technical support. Bbc3 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Bbc3 mouse model?
We have 2 Bbc3 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Bbc3 Mouse Model Types
A Bbc3 knockout mouse has the Bbc3 gene permanently inactivated, enabling loss of function studies. A Bbc3 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Bbc3, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Bbc3 organized by modification type. Each URL is indexable and matches common search patterns.