Conventional / global / constitutive KO
●2 Models Available
Bcl2 Conditional Knockout, Knockout mouse models
Browse 2 Bcl2 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Bcl2 conditional knockout mouse, Bcl2 knockout mouse. Contact us for availability and fast turnaround.
Why model Bcl2
Bcl2 is the mouse ortholog of human BCL2 and encodes the founding antiapoptotic guardian of the mitochondrial pathway, a tail-anchored protein whose BH1, BH2, and BH3 helices form an elongated hydrophobic groove that captures the BH3 helices of activators and effectors, restraining BAX and BAK before permeabilization. Its oncogenic biology is dosage driven rather than mutational: the human t(14;18) translocation places BCL2 under immunoglobulin heavy chain control in follicular lymphoma, best recapitulated in mice by Emu-driven or conditionally activated overexpression rather than a point mutant. Nulls survive birth but develop polycystic kidneys, lymphoid involution, and hair greying. Because Bcl2l1, Mcl1, and Bcl2l2 buffer loss in most tissues, single deletion often looks silent. Epitope-matched humanization is the decisive design when venetoclax pharmacology is the endpoint, including engineered Gly101Val resistance, while conditional nulls and inducible overexpression alleles answer survival dependency and lymphomagenesis questions respectively.
What Bcl2 mouse models are available?
ingenious targeting laboratory offers 2 distinct Bcl2 (BCL2) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Bcl2 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Bcl2 allele types
Knockout, conditional, knockin, humanized, and related paths for Bcl2 (human BCL2). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Bcl2 catalog models
2 Bcl2 lines with QC documentation and technical support. Bcl2 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Bcl2 mouse model?
We have 2 Bcl2 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Bcl2 Mouse Model Types
A Bcl2 knockout mouse has the Bcl2 gene permanently inactivated, enabling loss of function studies. A Bcl2 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Bcl2, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Bcl2 organized by modification type. Each URL is indexable and matches common search patterns.