Conventional / global / constitutive KO
●2 Models Available
C5ar1 Conditional Knockout, Knockout mouse models
Browse 2 C5ar1 mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as C5ar1 conditional knockout mouse, C5ar1 knockout mouse. Request a quote within 24 hours.
Why model C5ar1
C5ar1 encodes C5aR1 (CD88), the mouse ortholog of human C5AR1, a Galphai-coupled seven-transmembrane receptor that engages the carboxy-terminal region and core of C5a through a two-site mechanism involving its acidic N-terminal segment and transmembrane pocket, then signals via PI3Kgamma, PLCbeta, and beta-arrestin to drive neutrophil chemotaxis, oxidative burst, granule release, tissue factor induction, and NLRP3 priming. Output is shaped by C5a desArg generated by carboxypeptidase N and by the decoy-like second receptor C5ar2, which lacks G protein coupling but modulates beta-arrestin dependent signaling; that pairing means C5ar1 deletion alone may not fully reproduce pharmacological blockade. Nulls are viable and protected in sepsis, ANCA vasculitis, and ischemia reperfusion models, the same axis targeted by avacopan. Choose conditional alleles with myeloid or endothelial Cre when cell of action is the question, and humanized knockins when antagonist potency or species-restricted binding governs the readout.
What C5ar1 mouse models are available?
ingenious targeting laboratory offers 2 distinct C5ar1 (C5AR1) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
C5ar1 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
C5ar1 allele types
Knockout, conditional, knockin, humanized, and related paths for C5ar1 (human C5AR1). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available C5ar1 catalog models
2 C5ar1 lines with QC documentation and technical support. C5ar1 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a C5ar1 mouse model?
We have 2 C5ar1 models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About C5ar1 Mouse Model Types
A C5ar1 knockout mouse has the C5ar1 gene permanently inactivated, enabling loss of function studies. A C5ar1 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of C5ar1, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for C5ar1 organized by modification type. Each URL is indexable and matches common search patterns.