Conventional / global / constitutive KO
●2 Models Available
Casp9 Conditional Knockout, Knockout mouse models
Browse 2 Casp9 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Casp9 conditional knockout mouse, Casp9 knockout mouse. Contact us for availability and fast turnaround.
Why model Casp9
Casp9, ortholog of human CASP9, encodes the initiator caspase of the intrinsic pathway, whose CARD docks onto the CARD ring of APAF1 after cytochrome c and dATP driven apoptosome assembly, converting the monomeric zymogen into a holoenzyme that cleaves and activates caspases 3 and 7. Activity is set by dimerization rather than proteolysis alone and is restrained by XIAP BIR3 binding and by inhibitory phosphorylation from AKT and ERK, so apoptosome stoichiometry and IAP tone both shape the threshold. Germline nulls show markedly reduced neural progenitor apoptosis, exencephaly, and perinatal lethality on sensitive backgrounds, mirroring Apaf1 and Casp3 deficiency and placing the axis firmly in brain development. No other caspase substitutes for apoptosome coupling, so redundancy is minimal. Conditional flox alleles with lineage-restricted Cre are the practical route past lethality, while catalytically dead knockins or CARD mutants answer whether a phenotype requires proteolysis or merely platform occupancy.
What Casp9 mouse models are available?
ingenious targeting laboratory offers 2 distinct Casp9 (CASP9) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Casp9 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Casp9 allele types
Knockout, conditional, knockin, humanized, and related paths for Casp9 (human CASP9). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Casp9 catalog models
2 Casp9 lines with QC documentation and technical support. Casp9 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Casp9 mouse model?
We have 2 Casp9 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Casp9 Mouse Model Types
A Casp9 knockout mouse has the Casp9 gene permanently inactivated, enabling loss of function studies. A Casp9 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Casp9, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Casp9 organized by modification type. Each URL is indexable and matches common search patterns.