Conventional / global / constitutive KO
●2 Models Available
Cdkn2b Conditional Knockout, Knockout mouse models
Browse 2 Cdkn2b mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Cdkn2b conditional knockout mouse, Cdkn2b knockout mouse. Request a quote within 24 hours.
Why model Cdkn2b
Cdkn2b, mouse ortholog of human CDKN2B, encodes p15INK4b, an ankyrin repeat INK4 family inhibitor that binds CDK4 and CDK6 monomers and prevents productive D-cyclin association, thereby holding RB hypophosphorylated. Unlike p16, p15 is strongly transcriptionally induced by TGF beta through SMAD3 and SMAD4 with FOXO cofactors, making it the principal effector of cytostatic TGF beta signaling in epithelial and hematopoietic cells, and it is also silenced by promoter hypermethylation in acute myeloid leukemia and myelodysplastic syndrome. Because CDKN2B sits immediately adjacent to CDKN2A within the 9p21 cluster, most human deletions remove both, so a mouse allele targeting p15 alone is the only way to assign phenotype to this gene. Null mice are viable and develop lymphoid hyperplasia and angiosarcoma at low penetrance, and p16 upregulation genuinely compensates for p15 loss, so compound Cdkn2a and Cdkn2b alleles are required for the human co-deletion state. Use isolated nulls for TGF beta cytostasis and compound deletions for 9p21 tumor modeling.
What Cdkn2b mouse models are available?
ingenious targeting laboratory offers 2 distinct Cdkn2b (CDKN2B) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cdkn2b model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cdkn2b allele types
Knockout, conditional, knockin, humanized, and related paths for Cdkn2b (human CDKN2B). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cdkn2b catalog models
2 Cdkn2b lines with QC documentation and technical support. Cdkn2b floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Cdkn2b mouse model?
We have 2 Cdkn2b models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cdkn2b Mouse Model Types
A Cdkn2b knockout mouse has the Cdkn2b gene permanently inactivated, enabling loss of function studies. A Cdkn2b conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cdkn2b, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Cdkn2b organized by modification type. Each URL is indexable and matches common search patterns.