Conventional / global / constitutive KO
●2 Models Available
Cfi Conditional Knockout, Knockout mouse models
Browse 2 Cfi mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Cfi conditional knockout mouse, Cfi knockout mouse. Request a quote within 24 hours.
Why model Cfi
Cfi, ortholog of human CFI, encodes complement factor I, the sole protease that irreversibly inactivates deposited C3b and C4b. The secreted two-chain enzyme couples a heavy chain of FIMAC, SRCR, and two LDL receptor class A modules to a chymotrypsin-like serine protease light chain that is unusual in requiring an allosteric partner: catalysis proceeds only when C3b or C4b is engaged with a cofactor such as factor H, membrane cofactor protein CD46, C4b-binding protein, or CR1, which explains both its exceptional specificity and its sequential cleavage of C3b at two arginine sites to yield iC3b and then C3dg. Human deficiency causes secondary C3 depletion with pyogenic infection, and heterozygous mutations predispose to atypical hemolytic uremic syndrome and macular degeneration. Nulls consume C3 spontaneously and lack compensating proteases. Deploy the null for uncontrolled amplification phenotypes, hepatocyte-conditional alleles to test liver source, and humanization when factor I supplementation or cofactor-dependent activity is measured.
What Cfi mouse models are available?
ingenious targeting laboratory offers 2 distinct Cfi (CFI) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cfi model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cfi allele types
Knockout, conditional, knockin, humanized, and related paths for Cfi (human CFI). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cfi catalog models
2 Cfi lines with QC documentation and technical support. Cfi floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Cfi mouse model?
We have 2 Cfi models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cfi Mouse Model Types
A Cfi knockout mouse has the Cfi gene permanently inactivated, enabling loss of function studies. A Cfi conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cfi, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Cfi organized by modification type. Each URL is indexable and matches common search patterns.