Conventional / global / constitutive KO
●2 Models Available
Cflar Conditional Knockout, Knockout mouse models
Browse 2 Cflar mouse models including conditional knockout, knockout variants — in stock and ready to ship from ingenious targeting laboratory. Available as Cflar conditional knockout mouse, Cflar knockout mouse. Request a quote within 24 hours.
Why model Cflar
Cflar encodes cellular FLICE inhibitory protein, the mouse ortholog of human CFLAR, a death effector domain protein recruited to FADD within death-inducing signaling complexes where it heterodimerizes with procaspase-8. The long isoform retains a catalytically dead caspase-like domain that paradoxically stabilizes partial caspase-8 activity sufficient for RIPK1 and CYLD cleavage while blocking full processing and apoptosis, whereas short isoforms truncate after the death effector domains and inhibit outright; abundance is set by NF-kappaB dependent transcription and rapid ITCH and cullin-3 mediated turnover, making CFLAR a labile rheostat between survival, apoptosis, and necroptosis. Germline deletion is embryonic lethal around E10.5 with cardiac and vascular failure, phenocopying Casp8 and Fadd loss, and is rescued by concurrent Ripk3 or Mlkl deficiency. Conditional flox alleles with keratinocyte, intestinal epithelial, or myeloid Cre are therefore required, and isoform-selective knockins are the tool of choice for separating long from short isoform function.
What Cflar mouse models are available?
ingenious targeting laboratory offers 2 distinct Cflar (CFLAR) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Cflar model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Cflar allele types
Knockout, conditional, knockin, humanized, and related paths for Cflar (human CFLAR). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Cflar catalog models
2 Cflar lines with QC documentation and technical support. Cflar floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Cflar mouse model?
We have 2 Cflar models in stock — including Conditional Knockout, Knockout types. In stock and ready to ship this week. All models come with full QC documentation, health certificates, and dedicated technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Cflar Mouse Model Types
A Cflar knockout mouse has the Cflar gene permanently inactivated, enabling loss of function studies. A Cflar conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Cflar, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Cflar organized by modification type. Each URL is indexable and matches common search patterns.