Conventional / global / constitutive KO
●2 Models Available
Chchd10 Conditional Knockout, Knockout mouse models
Browse 2 Chchd10 mouse models including conditional knockout, knockout variants from ingenious targeting laboratory. Available as Chchd10 conditional knockout mouse, Chchd10 knockout mouse. Contact us for availability and fast turnaround.
Why model Chchd10
Chchd10, ortholog of human CHCHD10, encodes a small twin CX9C motif protein imported into the mitochondrial intermembrane space by the MIA40 and CHCHD4 disulfide relay, where it associates with the MICOS complex through MIC60 and helps maintain cristae junction architecture and respiratory chain organization. Dominant substitutions including S59L cause amyotrophic lateral sclerosis with frontotemporal dementia, and G66V causes late-onset spinal muscular atrophy Jokela type, but the decisive genetic observation is that constitutive nulls are essentially phenotype-free while S59L knockin animals develop cardiomyopathy, mitochondrial integrated stress response activation and motor neuron loss. That contrast makes the allele choice unambiguous: a knockout answers dispensability, whereas a point knockin is required to model the aggregation-driven toxic gain of function that underlies patient disease. CHCHD2 heterodimerizes with CHCHD10 and buffers its loss, so include compound alleles when interpreting null results and score OMA1, DELE1 and ATF4 axis activation alongside neuromuscular endpoints.
What Chchd10 mouse models are available?
ingenious targeting laboratory offers 2 distinct Chchd10 (CHCHD10) catalog mouse models, featuring conditional knockout and standard knockout. Researchers can order pre-developed catalog lines or request a custom mouse model, including humanized, knockin, and transgenic variations with verified germline transmission.
| Model Availability | Allele Class Options |
|---|---|
| 2 Ready Catalog Lines | Conditional Knockout (cKO) |
| Custom Model Generation | Constitutive Knockout (KO) |
| Advanced Modifications | Humanized, Knockin, Transgenic |
- Quality Control
- Documented Germline Transmission
- Quality Control
- Strict United States QC Guidelines
- Quality Control
- Cryo or Live Dispatch Options
Chchd10 model types
PathAvailability
Knockout
Conditional knockout
Knockin
Humanized
Transgenic / overexpression
Prefer the order form? Order. Need an allele that is not listed? Request a quote.
Chchd10 allele types
Knockout, conditional, knockin, humanized, and related paths for Chchd10 (human CHCHD10). Catalog lines ship when inventory exists. Everything else is a generation quote.
Knockout
Conditional KO (floxed / loxP)
Inducible conditional KO (CreER / tet)
Tissue specific KO
Specify tissue or Cre driver on quote
Knockout first (tm1a / IKMC)
Convertible floxed allele pathway
Double / compound KO
Multi allele / compound knockout project
Large scale / BAC deletion
BAC scale deletion or targeting
Knockin
Point mutation KI
cDNA KI
Reporter KI (GFP, YFP, RFP, mCherry, tdTomato, lacZ, luciferase)
Tag KI (FLAG, HA, Myc, V5)
Conditional KI (e.g. Rosa26 LSL)
LSL or conditional expression knockin
Gene replacement KI
Humanized
Full gene replacement
Partial / domain humanized
Domain or partial humanization scope
Immune checkpoint humanized
Checkpoint IO humanization when gene is a checkpoint target
Single humanized
Double / multi humanized
Multi humanized / combination IO project
Transgenic
Random integration transgenic
Safe harbor (ROSA26, HPRT, H11, Col1a1)
Overexpression transgenic
BAC transgenic
BAC transgenic or large fragment insert
Cre / recombinase
Constitutive Cre driver
Inducible Cre (CreER / tet)
Tamoxifen or dox inducible Cre
Dual recombinase (Cre+Dre / Cre+Flp)
Dual recombinase breeding scheme
Flp driver
Flp or FRT derivative allele pairing
Reporter
Reporter knockin (gene specific)
Standalone reporter catalog (lineage tracing, constitutive, dual reporter)
Catalog reporter lines not tied to a single gene allele
Species / background
Rat KO / KI / transgenic
Specify rat on quote
Rabbit models
Specify rabbit on quote
C57BL/6 (B6J / B6N)
Background substrain on quote
BALB/c
129, NOD, NSG, FVB, CD1, DBA/2
Background strain on quote
Available Chchd10 catalog models
2 Chchd10 lines with QC documentation and technical support. Chchd10 floxed mice use loxP flanked alleles for Cre dependent tissue specific knockout.
Looking for a Chchd10 mouse model?
We have 2 Chchd10 models available — including Conditional Knockout, Knockout types. Contact us today for current availability and our fastest turnaround options. All models come with full QC documentation and technical support.
Best pricing in the industry. Get a quote in 24 hours. Our team of PhD scientists is available to help you select the right model for your research.
Order catalog model2
Models Available
2
Model Types
24 hrs
Quote Turnaround
Included
QC Documentation
About Chchd10 Mouse Model Types
A Chchd10 knockout mouse has the Chchd10 gene permanently inactivated, enabling loss of function studies. A Chchd10 conditional knockout (floxed) mouse carries loxP sites flanking a critical exon of Chchd10, allowing Cre recombinase dependent deletion in specific tissues or at specific timepoints.
Modifications available
Jump to catalog backed pages for Chchd10 organized by modification type. Each URL is indexable and matches common search patterns.